EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway

• Published in: Scientific reports Vol. 5; no. 1; p. 13574
• Main Authors: Tsai, Meng-Feng, Chang, Tzu-Hua, Wu, Shang-Gin, Yang, Hsiao-Yin, Hsu, Yi-Chiung, Yang, Pan-Chyr, Shih, Jin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.09.2015; Nature Publishing Group
• Subjects: 631/67/1612/1350; 631/80/86; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Cell Line, Tumor; Chemokine CXCL12 - metabolism; CXCL12 protein; CXCR4 protein; Ectopic expression; Epidermal growth factor; Epidermal growth factor receptors; Humanities and Social Sciences; Humans; Invasiveness; Lung cancer; Lung carcinoma; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Molecular modelling; multidisciplinary; Mutation; Mutation - genetics; Neoplasm Invasiveness; Non-small cell lung carcinoma; Pleural cavity; Pleural effusion; Pleural Effusion, Malignant - genetics; Pleural Effusion, Malignant - metabolism; Pleural Effusion, Malignant - pathology; Receptor, Epidermal Growth Factor - genetics; Receptors, CXCR4 - metabolism; Science; Signal Transduction; siRNA; Small cell lung carcinoma

Malignant pleural effusion (MPE) is a common clinical problem in non-small cell lung carcinoma (NSCLC) patients; however, the underlying mechanisms are still largely unknown. Recent studies indicate that the frequency of the L858R mutant form of the epidermal growth factor receptor (EGFR-L858R) is h...