EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway - Tsai, Meng-Feng; Chang, Tzu-Hua; Wu, Shang-Gin; Yang, Hsiao-Yin; Hsu, Yi-Chiung; Yang, Pan-Chyr; Shih, Jin-Yuan (Scientific reports, 2015)
Keywords: 631/67/1612/1350; 631/80/86; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Cell Line, Tumor; Chemokine CXCL12 - metabolism; CXCL12 protein; CXCR4 protein; Ectopic expression; Epidermal growth factor; Epidermal growth factor receptors; Humanities and Social Sciences; Humans; Invasiveness; Lung cancer; Lung carcinoma; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Molecular modelling; multidisciplinary; Mutation; Mutation - genetics; Neoplasm Invasiveness; Non-small cell lung carcinoma; Pleural cavity; Pleural effusion; Pleural Effusion, Malignant - genetics; Pleural Effusion, Malignant - metabolism; Pleural Effusion, Malignant - pathology; Receptor, Epidermal Growth Factor - genetics; Receptors, CXCR4 - metabolism; Science; Signal Transduction; siRNA; Small cell lung carcinoma