Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles

Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe 3 O 4 nanoparticles and stabilized by oleic acid. Aq...

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Published inProgress in biomaterials Vol. 8; no. 3; pp. 155 - 168
Main Authors Hiremath, Chinmay G., Heggnnavar, Geetha B., Kariduraganavar, Mahadevappa Y., Hiremath, Murigendra B.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019
Springer Nature B.V
Subjects
Acids
Antineoplastic drugs
Antitumor agents
Biomaterials
Chemistry and Materials Science
Chemotherapy
Conjugation
Curcumin
Cytotoxicity
Diethylene glycol
Drug delivery
Drug delivery systems
Electron micrographs
Folic acid
Hydrophobicity
Iron oxides
Magnetic fields
Materials Science
Nanocomposites
Nanoparticles
NMR
Nuclear magnetic resonance
Oleic acid
Original Research
Paclitaxel
Poloxamers
Quantitative analysis
Vitamin B
Pluronic
Curcumin
Folic acid
Magnetic nanoparticles
Paclitaxel
Online AccessGet full text

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Abstract Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe 3 O 4 nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84.34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94.2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12.5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34.7% and 59.5% was noted for paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field. Graphic abstract
AbstractList Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe3O4 nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84.34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94.2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12.5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34.7% and 59.5% was noted for paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field.Graphic abstract
Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe 3 O 4 nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84.34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94.2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12.5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34.7% and 59.5% was noted for paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field. Graphic abstract
Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe O nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84.34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94.2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12.5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34.7% and 59.5% was noted for paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field.
Author Hiremath, Chinmay G.
Heggnnavar, Geetha B.
Kariduraganavar, Mahadevappa Y.
Hiremath, Murigendra B.
Author_xml – sequence: 1
  givenname: Chinmay G.
  surname: Hiremath
  fullname: Hiremath, Chinmay G.
  organization: Department of Biotechnology and Microbiology, Karnatak University
– sequence: 2
  givenname: Geetha B.
  surname: Heggnnavar
  fullname: Heggnnavar, Geetha B.
  organization: Department of Chemistry, Karnatak University
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  givenname: Mahadevappa Y.
  surname: Kariduraganavar
  fullname: Kariduraganavar, Mahadevappa Y.
  organization: Department of Chemistry, Karnatak University
– sequence: 4
  givenname: Murigendra B.
  surname: Hiremath
  fullname: Hiremath, Murigendra B.
  email: murigendra@kud.ac.in, murigendra@gmail.com
  organization: Department of Biotechnology and Microbiology, Karnatak University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31197663$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords Pluronic
Curcumin
Folic acid
Magnetic nanoparticles
Paclitaxel
Language English
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Snippet Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus...
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SubjectTerms Acids
Antineoplastic drugs
Antitumor agents
Biomaterials
Chemistry and Materials Science
Chemotherapy
Conjugation
Curcumin
Cytotoxicity
Diethylene glycol
Drug delivery
Drug delivery systems
Electron micrographs
Folic acid
Hydrophobicity
Iron oxides
Magnetic fields
Materials Science
Nanocomposites
Nanoparticles
NMR
Nuclear magnetic resonance
Oleic acid
Original Research
Paclitaxel
Poloxamers
Quantitative analysis
Vitamin B
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Title Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles
URI https://link.springer.com/article/10.1007/s40204-019-0118-5
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