Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

• Published in: Scientific reports Vol. 6; no. 1; p. 38646
• Main Authors: Zhou, Wencheng, Mo, Xiaoting, Cui, Wenhui, Zhang, Zhihui, Li, Delin, Li, Liucheng, Xu, Liang, Yao, Hongwei, Gao, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.12.2016; Nature Publishing Group
• Subjects: 13; 13/1; 13/109; 13/51; 13/89; 13/95; 631/80/79/1902; 631/80/86; 82; 82/1; 82/29; 82/51; 82/80; Alveoli; Animals; Bleomycin; Cell Line; Epithelial cells; Epithelial-Mesenchymal Transition - drug effects; Fibrosis; Gene Silencing - drug effects; Humanities and Social Sciences; Lung diseases; Mesenchyme; Mice; Models, Biological; multidisciplinary; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - metabolism; Pulmonary Alveoli - pathology; Pulmonary fibrosis; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Rats; Rodents; Science; siRNA; Snail Family Transcription Factors - metabolism; Sulforaphane; Transforming growth factor; Transforming Growth Factor beta1 - pharmacology; Transforming growth factor-b1

Epithelial-mesenchymal transition (EMT) is a phenotype conversion that plays a critical role in the development of pulmonary fibrosis (PF). It is known that snail could regulate the progression of EMT. Nuclear factor erythroid 2 related factor 2 (Nrf2), a key regulator of antioxidant defense system,...