Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain

Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the Erb...

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Bibliographic Details
Published inScientific reports Vol. 6; no. 1; p. 31502
Main Authors Kawasaki, Yuki, Sakimura, Ayaka, Park, Chul Min, Tomaru, Rika, Tanaka, Tomohiro, Ozawa, Tatsuhiko, Zhou, Yue, Narita, Kaori, Kishi, Hiroyuki, Muraguchi, Atsushi, Sakurai, Hiroaki
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.08.2016
Nature Publishing Group
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