Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain
Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the Erb...
Saved in:
Published in | Scientific reports Vol. 6; no. 1; p. 31502 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
17.08.2016
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodimer, the most potent ErbB receptor dimer. Constitutive tyrosine phosphorylation of ErbB2 and ErbB3 was significantly decreased in phorbol ester- and growth factor-treated BT-474 and MDA-MB-453 cells. In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner. The target threonine residue corresponding to EGFR Thr-669 and the surrounding residues are highly conserved in ErbB2, but not in ErbB3. Therefore, we demonstrated ERK-mediated phosphorylation of ErbB2 at Thr-677 by generating phospho-specific monoclonal antibodies. Moreover, treatment with trametinib and SCH772984, inhibitors of the MEK-ERK pathway and substitution of Thr-677 to alanine impaired the feedback inhibition of ErbB2 and ErbB3. These results demonstrated that ERK-mediated phosphorylation of the conserved threonine is a common mechanism for the negative feedback control of active ErbB receptor dimers. |
---|---|
AbstractList | Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodimer, the most potent ErbB receptor dimer. Constitutive tyrosine phosphorylation of ErbB2 and ErbB3 was significantly decreased in phorbol ester- and growth factor-treated BT-474 and MDA-MB-453 cells. In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner. The target threonine residue corresponding to EGFR Thr-669 and the surrounding residues are highly conserved in ErbB2, but not in ErbB3. Therefore, we demonstrated ERK-mediated phosphorylation of ErbB2 at Thr-677 by generating phospho-specific monoclonal antibodies. Moreover, treatment with trametinib and SCH772984, inhibitors of the MEK-ERK pathway, and substitution of Thr-677 to alanine impaired the feedback inhibition of ErbB2 and ErbB3. These results demonstrated that ERK-mediated phosphorylation of the conserved threonine is a common mechanism for the negative feedback control of active ErbB receptor dimers. Abstract Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In the present study, we investigated in human breast cancer cells whether a similar mechanism plays a role in the feedback regulation of the ErbB2/ErbB3 heterodimer, the most potent ErbB receptor dimer. Constitutive tyrosine phosphorylation of ErbB2 and ErbB3 was significantly decreased in phorbol ester- and growth factor-treated BT-474 and MDA-MB-453 cells. In contrast to the decreased tyrosine phosphorylation, Phos-tag Western blot analysis revealed that TPA induced phosphorylation of ErbB2 in an ERK-dependent manner. The target threonine residue corresponding to EGFR Thr-669 and the surrounding residues are highly conserved in ErbB2, but not in ErbB3. Therefore, we demonstrated ERK-mediated phosphorylation of ErbB2 at Thr-677 by generating phospho-specific monoclonal antibodies. Moreover, treatment with trametinib and SCH772984, inhibitors of the MEK-ERK pathway and substitution of Thr-677 to alanine impaired the feedback inhibition of ErbB2 and ErbB3. These results demonstrated that ERK-mediated phosphorylation of the conserved threonine is a common mechanism for the negative feedback control of active ErbB receptor dimers. |
ArticleNumber | 31502 |
Author | Ozawa, Tatsuhiko Kishi, Hiroyuki Muraguchi, Atsushi Tomaru, Rika Narita, Kaori Sakimura, Ayaka Sakurai, Hiroaki Tanaka, Tomohiro Zhou, Yue Kawasaki, Yuki Park, Chul Min |
Author_xml | – sequence: 1 givenname: Yuki surname: Kawasaki fullname: Kawasaki, Yuki organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 2 givenname: Ayaka surname: Sakimura fullname: Sakimura, Ayaka organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 3 givenname: Chul Min surname: Park fullname: Park, Chul Min organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 4 givenname: Rika surname: Tomaru fullname: Tomaru, Rika organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 5 givenname: Tomohiro surname: Tanaka fullname: Tanaka, Tomohiro organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 6 givenname: Tatsuhiko surname: Ozawa fullname: Ozawa, Tatsuhiko organization: Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 7 givenname: Yue surname: Zhou fullname: Zhou, Yue organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 8 givenname: Kaori surname: Narita fullname: Narita, Kaori organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 9 givenname: Hiroyuki surname: Kishi fullname: Kishi, Hiroyuki organization: Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 10 givenname: Atsushi surname: Muraguchi fullname: Muraguchi, Atsushi organization: Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama – sequence: 11 givenname: Hiroaki surname: Sakurai fullname: Sakurai, Hiroaki organization: Department of Cancer Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27531070$$D View this record in MEDLINE/PubMed |
BookMark | eNplkV1LHDEUhkOxVKte9A-UAW9sYWo-TeamoLLaUqFQ2uuQZM64WWeSbTKz6L9vltVlq4GQj_PkzXl536O9EAMg9IHgLwQzdZYTLBkRmL5BBxRzUVNG6d7Ofh8d57zAZQjacNK8Q_tUCkawxAcoXgO01rj7ysUwpthXsatmyV7SauVNNfv1ox6g9WaEtlrOYy4zPfZm9DGsSbN-liGtSnmcJ4jBB6h8KAeoFtPDaAYYbDLlso2D8eEIve1Mn-H4aT1Ef65nv6--1bc_b75fXdzWTmA-1spaRYVSoJTkRkrOLSFS8c4QKwhuDRiHuxYUl7LBjjKlsJDMuMYJC5ayQ_R1o7ucbDHgoJgzvV4mP5j0qKPx-v9K8HN9F1eaN0qeU1wETp8EUvw7QR714LODvi9e4pQ1UYQq1XDGC3ryAl3EKYViT5MGM6YIY-eF-rShXIq5hNZtmyFYr5PU2yQL-3G3-y35nFsBPm-AXErhDtLOl6_U_gGVsqoz |
CitedBy_id | crossref_primary_10_3390_cancers13195004 crossref_primary_10_1155_2023_6726038 crossref_primary_10_18632_oncotarget_20534 crossref_primary_10_3390_molecules26082141 crossref_primary_10_1093_narcan_zcad001 crossref_primary_10_1158_1078_0432_CCR_20_3872 crossref_primary_10_1158_0008_5472_CAN_18_1001 crossref_primary_10_3390_cancers9040027 crossref_primary_10_1016_j_bbrc_2019_04_125 crossref_primary_10_3390_ijms23084258 crossref_primary_10_3390_cancers11030375 crossref_primary_10_1248_yakushi_16_00229_4 crossref_primary_10_1038_s41598_020_73835_1 crossref_primary_10_3892_ol_2017_7532 crossref_primary_10_1016_j_tips_2019_09_005 crossref_primary_10_1016_j_trsl_2018_12_007 crossref_primary_10_1158_1541_7786_MCR_20_0687 crossref_primary_10_1016_j_jprot_2022_104485 crossref_primary_10_3892_ol_2020_11760 |
Cites_doi | 10.1016/j.ccr.2014.02.025 10.1016/j.molcel.2009.04.034 10.1038/sj.onc.1210922 10.1111/cas.12225 10.1158/2159-8290.CD-13-0070 10.1126/science.1099314 10.1371/journal.pone.0052383 10.1016/S0014-4827(08)00404-7 10.1126/science.274.5295.2086 10.1016/j.febslet.2013.11.020 10.1172/JCI32278 10.1038/ncomms8679 10.1128/MCB.00375-09 10.1016/j.cell.2006.05.013 10.1073/pnas.0703854104 10.1016/j.febslet.2005.06.047 10.1016/j.cell.2006.05.028 10.1074/jbc.M102079200 10.1111/hel.12215 10.1038/cr.2014.99 10.1158/1078-0432.CCR-10-2200 10.1038/nrm3048 10.1016/j.phrs.2013.11.002 10.1038/nm.1966 10.1016/j.cell.2011.02.003 10.1111/j.1600-0854.2008.00788.x 10.1002/jcp.21635 10.1038/sj.onc.1203973 10.1016/j.cell.2009.04.025 10.1074/jbc.M111.264945 10.1073/pnas.1537685100 10.1242/jcs.083303 10.1056/NEJMoa040938 10.1016/j.cellsig.2005.03.026 10.1038/nrc2088 10.1038/nm.3388 10.1016/j.ctrv.2015.08.001 10.2217/pgs.14.133 |
ContentType | Journal Article |
Copyright | The Author(s) 2016 Copyright Nature Publishing Group Aug 2016 Copyright © 2016, The Author(s) 2016 The Author(s) |
Copyright_xml | – notice: The Author(s) 2016 – notice: Copyright Nature Publishing Group Aug 2016 – notice: Copyright © 2016, The Author(s) 2016 The Author(s) |
DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
DOI | 10.1038/srep31502 |
DatabaseName | Springer_OA刊 Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest - Health & Medical Complete保健、医学与药学数据库 ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE Publicly Available Content Database |
Database_xml | – sequence: 1 dbid: C6C name: SpringerOpen url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2045-2322 |
EndPage | 31502 |
ExternalDocumentID | 10_1038_srep31502 27531070 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP CGR CUY CVF ECM EIF NPM AAYXX AFPKN CITATION 7XB 8FK K9. PQEST PQUKI PRINS Q9U 7X8 5PM |
ID | FETCH-LOGICAL-c504t-8bb82588e8874a7744b11784fa1b510daeac0fde847790c23880573ac9c5beb23 |
IEDL.DBID | RPM |
ISSN | 2045-2322 |
IngestDate | Tue Sep 17 21:14:30 EDT 2024 Fri Oct 25 21:26:11 EDT 2024 Thu Oct 10 18:50:26 EDT 2024 Fri Aug 23 02:54:43 EDT 2024 Wed Oct 16 00:58:38 EDT 2024 Fri Oct 11 20:55:30 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c504t-8bb82588e8874a7744b11784fa1b510daeac0fde847790c23880573ac9c5beb23 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987620/ |
PMID | 27531070 |
PQID | 1903381336 |
PQPubID | 2041939 |
PageCount | 1 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4987620 proquest_miscellaneous_1812889434 proquest_journals_1903381336 crossref_primary_10_1038_srep31502 pubmed_primary_27531070 springer_journals_10_1038_srep31502 |
PublicationCentury | 2000 |
PublicationDate | 2016-08-17 |
PublicationDateYYYYMMDD | 2016-08-17 |
PublicationDate_xml | – month: 08 year: 2016 text: 2016-08-17 day: 17 |
PublicationDecade | 2010 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationTitle | Scientific reports |
PublicationTitleAbbrev | Sci Rep |
PublicationTitleAlternate | Sci Rep |
PublicationYear | 2016 |
Publisher | Nature Publishing Group UK Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
References | Singh, Harris (CR3) 2005; 17 Zhang, Gureasko, Shen, Cole, Kuriyan (CR20) 2006; 125 Gilmartin (CR37) 2011; 17 Red Brewer (CR24) 2009; 34 Morris (CR29) 2013; 3 Sorkin, Goh (CR4) 2008; 314 Sun (CR32) 2011; 144 CR15 Galperin, Sorkin (CR30) 2008; 9 Zaidi (CR19) 2015; 20 Zhou (CR17) 2015; 6 Arteaga, Engelman (CR7) 2014; 25 Ozawa (CR28) 2012; 7 Vieira, Lamaze, Schmid (CR31) 1996; 274 Avraham, Yarden (CR5) 2011; 12 Sharma, Bell, Settleman, Haber (CR10) 2007; 7 Holbro (CR14) 2003; 100 Chong, Jänne (CR36) 2013; 19 Sebastian (CR1) 2006; 1766 Segatto, Anastasi, Alemà (CR35) 2011; 124 Zhou (CR39) 2014; 588 Roskoski (CR6) 2014; 79 Chung, Kim, Kim, Yim, Chock (CR38) 2011; 286 Nishimura (CR18) 2009; 29 Thiel, Carpenter (CR22) 2007; 104 Paez (CR9) 2004; 304 Zhu (CR33) 2007; 27 Jura (CR23) 2009; 137 Harari, Yarden (CR12) 2000; 19 Sato (CR25) 2013; 104 D’Amato (CR16) 2015; 41 Wang (CR34) 2014; 24 Hubbard (CR21) 2006; 125 Jin (CR27) 2009; 15 Lynch (CR8) 2004; 350 Dubská, Andera, Sheard (CR26) 2005; 579 Zhang (CR11) 2007; 117 Schneider, Wolf (CR2) 2009; 218 Hellyer, Kim, Koland (CR13) 2001; 276 24269963 - Pharmacol Res. 2014 Jan;79:34-74 12853564 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8933-8 19563760 - Cell. 2009 Jun 26;137(7):1293-307 11156523 - Oncogene. 2000 Dec 11;19(53):6102-14 21376233 - Cell. 2011 Mar 4;144(5):703-18 11546794 - J Biol Chem. 2001 Nov 9;276(45):42153-61 19560417 - Mol Cell. 2009 Jun 26;34(6):641-51 25704183 - Helicobacter. 2015 Oct;20(5):381-9 16023111 - FEBS Lett. 2005 Aug 1;579(19):4149-58 16777603 - Cell. 2006 Jun 16;125(6):1137-49 21705328 - J Biol Chem. 2011 Aug 26;286(34):29681-90 17318210 - Nat Rev Cancer. 2007 Mar;7(3):169-81 24202392 - Nat Med. 2013 Nov;19(11):1389-400 18793634 - Exp Cell Res. 2008 Oct 15;314(17):3093-106 8953040 - Science. 1996 Dec 20;274(5295):2086-9 19687304 - Mol Cell Biol. 2009 Oct;29(20):5529-39 21252999 - Nat Rev Mol Cell Biol. 2011 Feb;12(2):104-17 25712189 - Pharmacogenomics. 2015 ;16(3):257-71 19006176 - J Cell Physiol. 2009 Mar;218(3):460-6 23614898 - Cancer Discov. 2013 Jul;3(7):742-50 24651011 - Cancer Cell. 2014 Mar 17;25(3):282-303 18657070 - Traffic. 2008 Sep;9(10):1776-90 18042729 - Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19238-43 26158630 - Nat Commun. 2015 Jul 09;6:7679 19684583 - Nat Med. 2009 Sep;15(9):1088-92 21245089 - Clin Cancer Res. 2011 Mar 1;17(5):989-1000 15982853 - Cell Signal. 2005 Oct;17(10):1183-93 23300658 - PLoS One. 2012;7(12):e52383 17982484 - Oncogene. 2008 Apr 17;27(18):2525-31 23822636 - Cancer Sci. 2013 Oct;104(10):1315-22 15118073 - N Engl J Med. 2004 May 20;350(21):2129-39 24269888 - FEBS Lett. 2014 Jan 3;588(1):131-7 17671639 - J Clin Invest. 2007 Aug;117(8):2051-8 21576352 - J Cell Sci. 2011 Jun 1;124(Pt 11):1785-93 16889899 - Biochim Biophys Acta. 2006 Aug;1766(1):120-39 16777592 - Cell. 2006 Jun 16;125(6):1029-31 25081058 - Cell Res. 2014 Sep;24(9):1067-90 15118125 - Science. 2004 Jun 4;304(5676):1497-500 26276735 - Cancer Treat Rev. 2015 Dec;41(10):877-83 A Jin (BFsrep31502_CR27) 2009; 15 J-H Zhu (BFsrep31502_CR33) 2007; 27 A Sorkin (BFsrep31502_CR4) 2008; 314 N Jura (BFsrep31502_CR23) 2009; 137 T Holbro (BFsrep31502_CR14) 2003; 100 L Dubská (BFsrep31502_CR26) 2005; 579 JG Paez (BFsrep31502_CR9) 2004; 304 V D’Amato (BFsrep31502_CR16) 2015; 41 S Sebastian (BFsrep31502_CR1) 2006; 1766 H-M Wang (BFsrep31502_CR34) 2014; 24 X Zhang (BFsrep31502_CR20) 2006; 125 T Sun (BFsrep31502_CR32) 2011; 144 E Galperin (BFsrep31502_CR30) 2008; 9 D Harari (BFsrep31502_CR12) 2000; 19 NJ Hellyer (BFsrep31502_CR13) 2001; 276 MR Schneider (BFsrep31502_CR2) 2009; 218 R Avraham (BFsrep31502_CR5) 2011; 12 SF Zaidi (BFsrep31502_CR19) 2015; 20 SR Hubbard (BFsrep31502_CR21) 2006; 125 AB Singh (BFsrep31502_CR3) 2005; 17 M Red Brewer (BFsrep31502_CR24) 2009; 34 AG Gilmartin (BFsrep31502_CR37) 2011; 17 AV Vieira (BFsrep31502_CR31) 1996; 274 R Roskoski Jr. (BFsrep31502_CR6) 2014; 79 SV Sharma (BFsrep31502_CR10) 2007; 7 BFsrep31502_CR15 K Sato (BFsrep31502_CR25) 2013; 104 CL Arteaga (BFsrep31502_CR7) 2014; 25 YW Chung (BFsrep31502_CR38) 2011; 286 EJ Morris (BFsrep31502_CR29) 2013; 3 KW Thiel (BFsrep31502_CR22) 2007; 104 CR Chong (BFsrep31502_CR36) 2013; 19 H Zhang (BFsrep31502_CR11) 2007; 117 Y Zhou (BFsrep31502_CR17) 2015; 6 TJ Lynch (BFsrep31502_CR8) 2004; 350 M Nishimura (BFsrep31502_CR18) 2009; 29 T Ozawa (BFsrep31502_CR28) 2012; 7 Y Zhou (BFsrep31502_CR39) 2014; 588 O Segatto (BFsrep31502_CR35) 2011; 124 |
References_xml | – volume: 25 start-page: 282 year: 2014 end-page: 303 ident: CR7 article-title: ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.02.025 contributor: fullname: Engelman – volume: 34 start-page: 641 year: 2009 end-page: 651 ident: CR24 article-title: The juxtamembrane region of the EGF receptor functions as an activation domain publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.04.034 contributor: fullname: Red Brewer – volume: 27 start-page: 2525 year: 2007 end-page: 2531 ident: CR33 article-title: Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling publication-title: Oncogene doi: 10.1038/sj.onc.1210922 contributor: fullname: Zhu – volume: 104 start-page: 1315 year: 2013 end-page: 1322 ident: CR25 article-title: Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation publication-title: Cancer Sci. doi: 10.1111/cas.12225 contributor: fullname: Sato – volume: 3 start-page: 742 year: 2013 end-page: 750 ident: CR29 article-title: Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-0070 contributor: fullname: Morris – volume: 304 start-page: 1497 year: 2004 end-page: 1500 ident: CR9 article-title: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy publication-title: Science doi: 10.1126/science.1099314 contributor: fullname: Paez – volume: 7 start-page: e52383 year: 2012 ident: CR28 article-title: A Novel Rabbit Immunospot Array Assay on a Chip Allows for the Rapid Generation of Rabbit Monoclonal Antibodies with High Affinity publication-title: PLoS ONE doi: 10.1371/journal.pone.0052383 contributor: fullname: Ozawa – volume: 314 start-page: 3093 year: 2008 end-page: 3106 ident: CR4 article-title: Endocytosis and intracellular trafficking of ErbBs publication-title: Exp. Cell Res. doi: 10.1016/S0014-4827(08)00404-7 contributor: fullname: Goh – volume: 274 start-page: 2086 year: 1996 end-page: 2089 ident: CR31 article-title: Control of EGF receptor signaling by clathrin-mediated endocytosis publication-title: Science doi: 10.1126/science.274.5295.2086 contributor: fullname: Schmid – volume: 588 start-page: 131 year: 2014 end-page: 137 ident: CR39 article-title: p38-Mediated phosphorylation of Eps15 endocytic adaptor protein publication-title: FEBS Lett. doi: 10.1016/j.febslet.2013.11.020 contributor: fullname: Zhou – volume: 117 start-page: 2051 year: 2007 end-page: 2058 ident: CR11 article-title: ErbB receptors: from oncogenes to targeted cancer therapies publication-title: J. Clin. Invest. doi: 10.1172/JCI32278 contributor: fullname: Zhang – volume: 6 start-page: 7679 year: 2015 ident: CR17 article-title: Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2 publication-title: Nat. Commun. doi: 10.1038/ncomms8679 contributor: fullname: Zhou – volume: 29 start-page: 5529 year: 2009 end-page: 5539 ident: CR18 article-title: TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00375-09 contributor: fullname: Nishimura – volume: 125 start-page: 1137 year: 2006 end-page: 1149 ident: CR20 article-title: An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor publication-title: Cell doi: 10.1016/j.cell.2006.05.013 contributor: fullname: Kuriyan – volume: 104 start-page: 19238 year: 2007 end-page: 19243 ident: CR22 article-title: Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0703854104 contributor: fullname: Carpenter – volume: 579 start-page: 4149 year: 2005 end-page: 4158 ident: CR26 article-title: HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis publication-title: FEBS Lett. doi: 10.1016/j.febslet.2005.06.047 contributor: fullname: Sheard – volume: 125 start-page: 1029 year: 2006 end-page: 1031 ident: CR21 article-title: EGF receptor activation: push comes to shove publication-title: Cell doi: 10.1016/j.cell.2006.05.028 contributor: fullname: Hubbard – volume: 276 start-page: 42153 year: 2001 end-page: 42161 ident: CR13 article-title: Heregulin-dependent Activation of Phosphoinositide 3-Kinase and Akt via the ErbB2/ErbB3 Co-receptor publication-title: J. Biol. Chem. doi: 10.1074/jbc.M102079200 contributor: fullname: Koland – ident: CR15 – volume: 20 start-page: 381 year: 2015 end-page: 390 ident: CR19 article-title: Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner publication-title: Helicobacter doi: 10.1111/hel.12215 contributor: fullname: Zaidi – volume: 24 start-page: 1067 year: 2014 end-page: 1090 ident: CR34 article-title: The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes publication-title: Cell Res doi: 10.1038/cr.2014.99 contributor: fullname: Wang – volume: 17 start-page: 989 year: 2011 end-page: 1000 ident: CR37 article-title: GSK1120212 (JTP-74057) is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained Pathway Inhibition publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-10-2200 contributor: fullname: Gilmartin – volume: 12 start-page: 104 year: 2011 end-page: 117 ident: CR5 article-title: Feedback regulation of EGFR signalling: decision making by early and delayed loops publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3048 contributor: fullname: Yarden – volume: 1766 start-page: 120 year: 2006 end-page: 139 ident: CR1 article-title: The complexity of targeting EGFR signalling in cancer: from expression to turnover publication-title: Biochim. Biophys. Acta contributor: fullname: Sebastian – volume: 79 start-page: 34 year: 2014 end-page: 74 ident: CR6 article-title: The ErbB/HER family of protein-tyrosine kinases and cancer publication-title: Pharmacological Research doi: 10.1016/j.phrs.2013.11.002 contributor: fullname: Roskoski – volume: 15 start-page: 1088 year: 2009 end-page: 1092 ident: CR27 article-title: A rapid and efficient single-cell manipulation method for screening antigen-specific antibody–secreting cells from human peripheral blood publication-title: Nat. Med. doi: 10.1038/nm.1966 contributor: fullname: Jin – volume: 144 start-page: 703 year: 2011 end-page: 718 ident: CR32 article-title: Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase publication-title: Cell doi: 10.1016/j.cell.2011.02.003 contributor: fullname: Sun – volume: 9 start-page: 1776 year: 2008 end-page: 1790 ident: CR30 article-title: Endosomal Targeting of MEK2 Requires RAF, MEK Kinase Activity and Clathrin-Dependent Endocytosis publication-title: Traffic doi: 10.1111/j.1600-0854.2008.00788.x contributor: fullname: Sorkin – volume: 218 start-page: 460 year: 2009 end-page: 466 ident: CR2 article-title: The epidermal growth factor receptor ligands at a glance publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21635 contributor: fullname: Wolf – volume: 19 start-page: 6102 year: 2000 end-page: 6114 ident: CR12 article-title: Molecular mechanisms underlying ErbB2/HER2 action in breast cancer publication-title: Oncogene doi: 10.1038/sj.onc.1203973 contributor: fullname: Yarden – volume: 137 start-page: 1293 year: 2009 end-page: 1307 ident: CR23 article-title: Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment publication-title: Cell doi: 10.1016/j.cell.2009.04.025 contributor: fullname: Jura – volume: 286 start-page: 29681 year: 2011 end-page: 29690 ident: CR38 article-title: Dual function of protein kinase C (PKC) in 12- -tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-α phosphorylation and by PKC-mediated inactivation of Akt, respectively publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.264945 contributor: fullname: Chock – volume: 100 start-page: 8933 year: 2003 end-page: 8938 ident: CR14 article-title: The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1537685100 contributor: fullname: Holbro – volume: 124 start-page: 1785 year: 2011 end-page: 1793 ident: CR35 article-title: Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors publication-title: J. Cell. Sci. doi: 10.1242/jcs.083303 contributor: fullname: Alemà – volume: 350 start-page: 2129 year: 2004 end-page: 2139 ident: CR8 article-title: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa040938 contributor: fullname: Lynch – volume: 17 start-page: 1183 year: 2005 end-page: 1193 ident: CR3 article-title: Autocrine, paracrine and juxtacrine signaling by EGFR ligands publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2005.03.026 contributor: fullname: Harris – volume: 7 start-page: 169 year: 2007 end-page: 181 ident: CR10 article-title: Epidermal growth factor receptor mutations in lung cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2088 contributor: fullname: Haber – volume: 19 start-page: 1389 year: 2013 end-page: 1400 ident: CR36 article-title: The quest to overcome resistance to EGFR-targeted therapies in cancer publication-title: Nat. Med. doi: 10.1038/nm.3388 contributor: fullname: Jänne – volume: 41 start-page: 877 year: 2015 end-page: 883 ident: CR16 article-title: Mechanisms of lapatinib resistance in HER2-driven breast cancer publication-title: Cancer Treatment Reviews doi: 10.1016/j.ctrv.2015.08.001 contributor: fullname: D’Amato – volume: 124 start-page: 1785 year: 2011 ident: BFsrep31502_CR35 publication-title: J. Cell. Sci. doi: 10.1242/jcs.083303 contributor: fullname: O Segatto – volume: 20 start-page: 381 year: 2015 ident: BFsrep31502_CR19 publication-title: Helicobacter doi: 10.1111/hel.12215 contributor: fullname: SF Zaidi – volume: 7 start-page: 169 year: 2007 ident: BFsrep31502_CR10 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2088 contributor: fullname: SV Sharma – volume: 104 start-page: 19238 year: 2007 ident: BFsrep31502_CR22 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0703854104 contributor: fullname: KW Thiel – volume: 274 start-page: 2086 year: 1996 ident: BFsrep31502_CR31 publication-title: Science doi: 10.1126/science.274.5295.2086 contributor: fullname: AV Vieira – volume: 579 start-page: 4149 year: 2005 ident: BFsrep31502_CR26 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2005.06.047 contributor: fullname: L Dubská – volume: 17 start-page: 1183 year: 2005 ident: BFsrep31502_CR3 publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2005.03.026 contributor: fullname: AB Singh – volume: 276 start-page: 42153 year: 2001 ident: BFsrep31502_CR13 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M102079200 contributor: fullname: NJ Hellyer – volume: 27 start-page: 2525 year: 2007 ident: BFsrep31502_CR33 publication-title: Oncogene doi: 10.1038/sj.onc.1210922 contributor: fullname: J-H Zhu – volume: 1766 start-page: 120 year: 2006 ident: BFsrep31502_CR1 publication-title: Biochim. Biophys. Acta contributor: fullname: S Sebastian – volume: 15 start-page: 1088 year: 2009 ident: BFsrep31502_CR27 publication-title: Nat. Med. doi: 10.1038/nm.1966 contributor: fullname: A Jin – volume: 6 start-page: 7679 year: 2015 ident: BFsrep31502_CR17 publication-title: Nat. Commun. doi: 10.1038/ncomms8679 contributor: fullname: Y Zhou – volume: 7 start-page: e52383 year: 2012 ident: BFsrep31502_CR28 publication-title: PLoS ONE doi: 10.1371/journal.pone.0052383 contributor: fullname: T Ozawa – volume: 29 start-page: 5529 year: 2009 ident: BFsrep31502_CR18 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00375-09 contributor: fullname: M Nishimura – ident: BFsrep31502_CR15 doi: 10.2217/pgs.14.133 – volume: 17 start-page: 989 year: 2011 ident: BFsrep31502_CR37 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-10-2200 contributor: fullname: AG Gilmartin – volume: 19 start-page: 1389 year: 2013 ident: BFsrep31502_CR36 publication-title: Nat. Med. doi: 10.1038/nm.3388 contributor: fullname: CR Chong – volume: 79 start-page: 34 year: 2014 ident: BFsrep31502_CR6 publication-title: Pharmacological Research doi: 10.1016/j.phrs.2013.11.002 contributor: fullname: R Roskoski Jr. – volume: 314 start-page: 3093 year: 2008 ident: BFsrep31502_CR4 publication-title: Exp. Cell Res. doi: 10.1016/S0014-4827(08)00404-7 contributor: fullname: A Sorkin – volume: 100 start-page: 8933 year: 2003 ident: BFsrep31502_CR14 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1537685100 contributor: fullname: T Holbro – volume: 144 start-page: 703 year: 2011 ident: BFsrep31502_CR32 publication-title: Cell doi: 10.1016/j.cell.2011.02.003 contributor: fullname: T Sun – volume: 588 start-page: 131 year: 2014 ident: BFsrep31502_CR39 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2013.11.020 contributor: fullname: Y Zhou – volume: 25 start-page: 282 year: 2014 ident: BFsrep31502_CR7 publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.02.025 contributor: fullname: CL Arteaga – volume: 304 start-page: 1497 year: 2004 ident: BFsrep31502_CR9 publication-title: Science doi: 10.1126/science.1099314 contributor: fullname: JG Paez – volume: 19 start-page: 6102 year: 2000 ident: BFsrep31502_CR12 publication-title: Oncogene doi: 10.1038/sj.onc.1203973 contributor: fullname: D Harari – volume: 12 start-page: 104 year: 2011 ident: BFsrep31502_CR5 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3048 contributor: fullname: R Avraham – volume: 41 start-page: 877 year: 2015 ident: BFsrep31502_CR16 publication-title: Cancer Treatment Reviews doi: 10.1016/j.ctrv.2015.08.001 contributor: fullname: V D’Amato – volume: 104 start-page: 1315 year: 2013 ident: BFsrep31502_CR25 publication-title: Cancer Sci. doi: 10.1111/cas.12225 contributor: fullname: K Sato – volume: 218 start-page: 460 year: 2009 ident: BFsrep31502_CR2 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21635 contributor: fullname: MR Schneider – volume: 137 start-page: 1293 year: 2009 ident: BFsrep31502_CR23 publication-title: Cell doi: 10.1016/j.cell.2009.04.025 contributor: fullname: N Jura – volume: 117 start-page: 2051 year: 2007 ident: BFsrep31502_CR11 publication-title: J. Clin. Invest. doi: 10.1172/JCI32278 contributor: fullname: H Zhang – volume: 24 start-page: 1067 year: 2014 ident: BFsrep31502_CR34 publication-title: Cell Res doi: 10.1038/cr.2014.99 contributor: fullname: H-M Wang – volume: 125 start-page: 1029 year: 2006 ident: BFsrep31502_CR21 publication-title: Cell doi: 10.1016/j.cell.2006.05.028 contributor: fullname: SR Hubbard – volume: 9 start-page: 1776 year: 2008 ident: BFsrep31502_CR30 publication-title: Traffic doi: 10.1111/j.1600-0854.2008.00788.x contributor: fullname: E Galperin – volume: 286 start-page: 29681 year: 2011 ident: BFsrep31502_CR38 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.264945 contributor: fullname: YW Chung – volume: 350 start-page: 2129 year: 2004 ident: BFsrep31502_CR8 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa040938 contributor: fullname: TJ Lynch – volume: 3 start-page: 742 year: 2013 ident: BFsrep31502_CR29 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-0070 contributor: fullname: EJ Morris – volume: 34 start-page: 641 year: 2009 ident: BFsrep31502_CR24 publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.04.034 contributor: fullname: M Red Brewer – volume: 125 start-page: 1137 year: 2006 ident: BFsrep31502_CR20 publication-title: Cell doi: 10.1016/j.cell.2006.05.013 contributor: fullname: X Zhang |
SSID | ssj0000529419 |
Score | 2.3267584 |
Snippet | Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane domain. In... Abstract Tyrosine kinase activity of the asymmetric EGFR homodimer is negatively regulated via ERK-mediated phosphorylation of Thr-669 in the juxtamembrane... |
SourceID | pubmedcentral proquest crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 31502 |
SubjectTerms | 631/67/395 631/80/86/2368 96/95 Alanine Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Line, Tumor Epidermal growth factor receptors ErbB protein ErbB-2 protein ErbB-3 protein Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Feedback inhibition Female HEK293 Cells Humanities and Social Sciences Humans Kinases Metabolic pathways Monoclonal antibodies multidisciplinary Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Phosphorylation Phosphorylation - genetics Protein Domains Protein-tyrosine kinase Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Science Threonine Threonine - genetics Threonine - metabolism |
SummonAdditionalLinks | – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVkhcEO8uLcg8rlETx0mcE6JoVxWIClVU6i3yK-qCNtnuZhH99_2cF2wrccghsa04Hnvmm0dmiD6koU4d5zqIbJIFwso80LkDM0xNxkuIsMh4g_630_TkXHy5SC56g9umD6sceGLLqG1tvI38CIIL2hQ0qvTj6irwVaO8d7UvoXGf9rjP3DShvePZ6fez0cri_VgiyoeUQrE8guBZxUBBfFcQ3UGXd4Mkb3lKWwE0f0yPeuTIPnWkfkL3XPWUHnS1JK-fUT2HHNLK_GJ99DmrSzZb62POfi8Um519Ddq_RIAw2eqy3uBaX3eBcL6n8sO8hRbNDejrrbSOLSrcOPZz-6dRS7eEZo2Htl6qRfWczuezH59Pgr6aQmCSUDSB1BraoJQObEUooD6hoyiTolSRxsG0Ciw4LK2DuMry0HCfJSbJYmVyk2jo3_ELmlR15faJuViVViXGgpDCRqESKTfcCctVkkojpvRuWNpi1SXNKFpndyyLcf2ndDgsetGfm03xl8pTejs2Y8d7NwY-sd6iDzCJ9Gnj8Z6XHY3Gt3BoX1BowyllO9QbO_hs2rst1eKyzaotci8YMPL9QOd_pnV78q_-P_kDeghglXrbc5Qd0qRZb91rgJdGv-l36A0GD_Lg priority: 102 providerName: ProQuest – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwELYQVSUuFaVAFygyj2sgcZzEOVQVVLtCreCAWIlb5FfEtmyyLFnE_vt-zmPFQg8cckhsy86MPfPN2J4h5Dj2VWwZU15gosTjRqSeSi2EYawTlkOFBdo59C-v4osh_3Ub3a6QLsdmS8DH_5p2Lp_UcHp_8vww_4EF_725Mi5OoUsmIYANJPEHxsPQTe7LFuU3Ib5ZyoO0iyv0ssWyNnoDMd-elHy1XVprocE6-dTCR3rW8PszWbHFBvnYJJScfyHlAMpISf2XtkfQaZnT_lSdM_o0krR__durr4oAZtLJXfmIZzpvTsO5mtI1c25aFFdgsnPVWjoq8GLpn9lzJcd2DPMaH005lqNikwwH_ZufF16bUsHTkc8rTygFk1AIC9nCJaAfV0GQCJ7LQGF1Ggk57OfGQmclqa-ZCxUTJaHUqY4UjPBwi6wWZWG_EmpDmRsZaQNuchP4ksdMM8sNk1EsNO-Rw4602aSJnJHVO96hyBb075G9juhZx_sMGAWGM4znuEcOFsWY9m4vA79YzlAHwES42PHoZ7vh0aIXBhMMVq3fI8kS9xYVXEjt5ZJidFeH1uap0w5oedTx-cWwXg9-5x2j2yVrgFix80IHyR5ZraYz-w0wplL79ST9B-hL9as priority: 102 providerName: Scholars Portal – databaseName: Springer_OA刊 dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwELYQqFIvVemDboHKQK8RseM4zhHQrlCr9oBA4hb5FbGgTVZLFsG_53OyiVi4cMgh8Vh2PPbMNzP2mJDfMjbSc24i5tIsEk7lkck9hKG0GS-hwpgNDv1__-X5lfhznV5vkIP-LMxa_D5Rx9AT8wSgBVJ2K2XQziEeK88GN0oIVAmW9zmDXtZY1zRv4OPbXZCvQqGthpl8Jp9W0JCedLzcJhu--kI-dJdFPn0l9QSKxmh7R1fby2ld0vHCnHL6MNV0fPE3ao-BAELS-U19j2fx1O10C5Q6VAsuWBQ3YGBww3o6rfDi6e3ysdEzP4PpjI-unulp9Y1cTcaXZ-fR6rqEyKaxaCJlDMw9pTzkhtCAdcIwlilRamaw8pyGjI1L56GPsjy2PKSBSbNE29ymBgZ28p1sVnXlfxDqE106nVoHTgnHYi0kt9wLx3UqlRUjctgPbTHvsmIUbTQ7UcUw_iOy1w96sVoY9wXwB4xiGMZyRA6GYkzpEKfAL9ZL0AB0qJAXHu3sdDwaWuEwr2CxxiOSrXFvIAjpstdLqulNmzZb5EHyo-ZRz-cX3Xrd-Z_votolHwGgZPAxs2yPbDaLpd8HSGnMr3aaPgOr4ueI priority: 102 providerName: Springer Nature |
Title | Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain |
URI | https://link.springer.com/article/10.1038/srep31502 https://www.ncbi.nlm.nih.gov/pubmed/27531070 https://www.proquest.com/docview/1903381336 https://search.proquest.com/docview/1812889434 https://pubmed.ncbi.nlm.nih.gov/PMC4987620 |
Volume | 6 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6SlEIvpe-6TRf1cXXWlmVJPjbLLqFlQwgN7M3oZeK2tpeNtzT_viM_lmxy68EGWbIla0aab0ajEcAXHmnuKNVhbFMRMiuzUGcOJ0NuBC1QhMXGG_SX5_zsin1bpasDSMe9MJ3TvtHlSf27OqnL6863cl2Z6egnNr1Yzljmx3A0PYRDkSR3VPQ-oDfNWJyNUYQSOUVZs04Q-PiTayjCc9R4on0x9ABbPnSRvLdO2omfxTN4OuBG8rVv33M4cPULeNyfJHn7EpoFSiGtzC8y-J6TpiDzjT6l5E-pyPzye9jtEUF8SdbXzQ1em9veDc6XVP41b5_F7Bap6220jpQ1Jhz5uf3bqspVqFfjQ9tUqqxfwdVi_mN2Fg5nKYQmjVgbSq1RF5TS4aTCFGI-puNYSFaoWOOwtAon4KiwDoWVyCJDfYyYVCTKZCbVqH0nr-Gobmr3FohLVGFVaiySkdk4UoxTQx2zVKVcGhbAp7Fr83UfMiPvlroTme9IEcDx2On5MGpucgQnqDGj1swD-LjLRn73ixj4i80WyyAikT5oPNbzpqfRrpaRuAGIPertCvhY2vs5yGJdTO2BpQL4PNL5TrPuN_7df3__PTxBxMW9UToWx3DUbrbuA6KaVk-Ql1diAo9O5-cXl5ia8dmksxDgfcnkpOPyf-6K_6s |
link.rule.ids | 230,315,733,786,790,870,891,12077,21409,24339,27946,27947,31743,31744,33768,33769,41144,42213,43334,43829,51600,53816,53818,74091,74648 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB5RqqpcUN9sS6lLe41IbCd2TlVb7WopjwMCaW-RXxFbtMmym63g33ecFyxIHHJIbCuOx5755pEZgO9JqBNHqQ4iG4uAW5kGOnXIDBMjaI4iLDLeoH9ymowv-J9JPGkNbss2rLLjiTWjtqXxNvIDFFyoTaFGlfyYXwe-apT3rrYlNJ7Bc84Y87nzxUT0NhbvxeJR2iUUYvIAxc6cIQai62LoEbZ8HCL5wE9ai5_RK9hucSP52RD6NWy44g28aCpJ3r6FcoRSSCtzRdrYc1LmZLjQvyj5N1VkeHYU1P-IIL4k88tyidfitgmD8z2VH-bts9hcIXW9jdaRaYE3jvxd3VRq5maoV-NDW87UtHgHF6Ph-e9x0NZSCEwc8iqQWqMuKKVDpsIVYj6uo0hInqtI47G0ChlwmFuHwkqkoaE-R0wsmDKpiTVq3-w9bBZl4XaAOKZyq2JjkYzcRqHiCTXUcUtVnEjDB7DfLW02b1JmZLWrm8msX_8B7HaLnrWnZpnd0XgAX_tm3O_eiYGfWK6wDyIS6ZPG43s-NDTq30JR90J1NhyAWKNe38Hn0l5vKaaXdU5tnnqxgCO_dXS-N62Hk__49OS_wMvx-clxdnx4evQJthBiJd4KHYld2KwWK_cZYUyl9-q9-h92_PRl |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bb9MwFLZgCMQL4jo6NjCX16iJ48TO0zRGq8FgQohJfYt8i1ZQk65NEfv3fM4Nukk85CGxrTg-9vnOLecQ8i4NdeoY00FkExFwK7NAZw7MMDWCFYCwyHiD_pez9OScf5olsy7-ad2FVfY8sWHUtjLeRj4GcEGbgkaVjosuLOLrh-nh8jLwFaS8p7Urp3Gb3BFQWvwhFTMx2Fu8R4tHWZ9cKJZjQNAyhjzEtiHphpx5M1zyms-0gaLpQ_KgkyHpUUv0R-SWKx-Tu21VyasnpJoCkbQyP2kXh06rgk5W-j2jv-aKTr6dBs3_IpA16fKiWuNaXbUhcb6n8sO8rRbNNSjt7bWOzkvcOPpj87tWC7eAjo2HtlqoefmUnE8n349Pgq6uQmCSkNeB1Bp6oZQODIYryH9cR5GQvFCRxhG1Csw4LKwDcIksNMzni0lErExmEg1NPH5GdsqqdM8JdbEqrEqMBUm5jULFU2aY45apJJWGj8ibfmnzZZs-I2_c3rHMh_Ufkf1-0fPuBK3zv_QekddDM_a-d2jgE6sN-kA6kT6BPN6z29JoeAuDHgbVNhwRsUW9oYPPq73dUs4vmvzaPPMQgZFvezr_M63rk9_7_-RfkXvYpvnnj2enL8h9SFupN0hHYp_s1KuNO4BEU-uXzVb9A6eN-Jo |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Feedback+control+of+ErbB2+via+ERK-mediated+phosphorylation+of+a+conserved+threonine+in+the+juxtamembrane+domain&rft.jtitle=Scientific+reports&rft.au=Kawasaki%2C+Yuki&rft.au=Sakimura%2C+Ayaka&rft.au=Park%2C+Chul+Min&rft.au=Tomaru%2C+Rika&rft.date=2016-08-17&rft.eissn=2045-2322&rft.volume=6&rft.spage=31502&rft.epage=31502&rft_id=info:doi/10.1038%2Fsrep31502&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |