Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19

• Published in: British journal of nutrition Vol. 127; no. 2; pp. 214 - 232
• Main Authors: Wessels, Inga, Rolles, Benjamin, Slusarenko, Alan J., Rink, Lothar
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.01.2022
• Subjects: adhesion; Apoptosis; Cell adhesion molecules; Cell death; Coronaviruses; cost effectiveness; COVID-19; COVID-19 - epidemiology; COVID-19 - pathology; COVID-19 infection; Dietary supplements; Disease; Disease Progression; hematopoiesis; human health; Human subjects; Humans; Immune response; Immune system; Immunology; Infections; Inflammation; Lymphocytes; Medical prognosis; metabolism; Nervous system; Nutrient deficiency; Nutrition; Nutritional Immunology; Parenteral nutrition; Patient Acuity; Patients; phenotype; Phenotypes; Pneumonia; Proteins; Respiratory diseases; Respiratory distress syndrome; Risk analysis; Risk Assessment; Risk Factors; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Signs and symptoms; therapeutics; tight junctions; Viral diseases; Viruses; Zinc; Zinc - deficiency; Iran; Impaired immune system; Corona Virus Disease 19; Zinc deficiency; Severe Acute Respiratory Syndrome-Coronavirus-2

The importance of Zn for human health becomes obvious during Zn deficiency. Even mild insufficiencies of Zn cause alterations in haematopoiesis and immune functions, resulting in a proinflammatory phenotype and a disturbed redox metabolism. Although immune system malfunction has the most obvious eff...