Variable impact of tizanidine on the medium latency reflex of upper and lower limbs

• Published in: Experimental brain research Vol. 236; no. 3; pp. 665 - 677
• Main Authors: Kurtzer, Isaac, Bouyer, Laurent J., Bouffard, J., Jin, A., Christiansen, L., Nielsen, J. B., Scott, S. H.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018; Springer; Springer Nature B.V
• Subjects: Adrenergic alpha-2 Receptor Agonists - pharmacology; Adult; Afferent Pathways - drug effects; Ankle; Arm; Biomedical and Life Sciences; Biomedicine; Clonidine - analogs & derivatives; Clonidine - pharmacology; Dosage and administration; Elbow; Electromyography; Female; Humans; Interneurons; Interneurons - drug effects; Latency; Leg; Legs; Lower Extremity - physiology; Male; Motor Activity - drug effects; Motor neurons; Motor Neurons - drug effects; Muscle, Skeletal - drug effects; Muscles; Neurology; Neurons, Afferent - drug effects; Neurosciences; Patient outcomes; Reflex - drug effects; Research Article; Robotics; Tizanidine; Upper Extremity - physiology; Walking; Young Adult; Limb control; Spinal reflex; Feedback; Group II afferents

Sudden limb displacement evokes a complex sequence of compensatory muscle activity. Following the short-latency reflex and preceding voluntary reactions is an epoch termed the medium-latency reflex (MLR) that could reflect spinal processing of group II muscle afferents. One way to test this possibil...