Cigarette Smoking, Genetic Variants in Carcinogen-metabolizing Enzymes, and Colorectal Cancer Risk

• Published in: American journal of epidemiology Vol. 172; no. 9; pp. 1000 - 1014
• Main Authors: Cleary, Sean P., Cotterchio, Michelle, Shi, Ellen, Gallinger, Steven, Harper, Patricia
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.11.2010; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases - genetics; Arylamine N-Acetyltransferase - genetics; Arylsulfotransferase - genetics; Biological and medical sciences; Biomarkers - blood; Carcinogens; Case-Control Studies; Cigarettes; Colon; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - etiology; Colorectal Neoplasms - genetics; Confidence Intervals; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1 - genetics; enzymes; Epidemiology; Epoxide Hydrolases - genetics; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; genes; Genetic diversity; Genetic variance; genetic variation; Genetics; Genotype; Genotypes; Glutathione Transferase - genetics; Health risks; Humans; Isoenzymes - genetics; Male; Medical Records; Medical sciences; Middle Aged; Miscellaneous; Multivariate Analysis; neoplasm; Odds Ratio; Ontario - epidemiology; Original Contributions; Polymorphism, Genetic; Public health. Hygiene; Public health. Hygiene-occupational medicine; Retrospective Studies; Risk; Risk reduction; Smoking; Smoking - adverse effects; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surveys and Questionnaires; Tobacco, tobacco smoking; Toxicology; Tumors; Ontario; Canada, Ontario; Rectal disease; Colorectal cancer; Tobacco smoking; Risk; enzymes; Epidemiology; Gene; colorectal neoplasms; smoking; Intestinal disease; Genetics; carcinogens; Public health; Enzyme; genes; Genetic variant; genetic variation; Malignant tumor; Colonic disease; Carcinogen; Tobacco; Risk factor; Digestive diseases; neoplasm; Cancer; Polymorphism

The risk of colorectal cancer associated with smoking is unclear and may be influenced by genetic variation in enzymes that metabolize cigarette carcinogens. The authors examined the colorectal cancer risk associated with smoking and 26 variants in carcinogen metabolism genes in 1,174 colorectal can...