Small molecule inhibitors of HCV replication from Pomegranate

• Published in: Scientific reports Vol. 4; no. 1; p. 5411
• Main Authors: Reddy, B. Uma, Mullick, Ranajoy, Kumar, Anuj, Sudha, Govindarajan, Srinivasan, Narayanaswamy, Das, Saumitra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.06.2014; Nature Publishing Group
• Subjects: 13; 13/106; 140/58; 631/326/596/1905; 631/92/613; 82; 82/29; 82/83; Animals; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - metabolism; Antiviral Agents - pharmacology; Cell culture; Cell Line, Tumor; Chromatography, High Pressure Liquid; Computer applications; Ellagic acid; Ellagic Acid - chemistry; Ellagic Acid - metabolism; Ellagic Acid - pharmacology; Hepacivirus - drug effects; Hepacivirus - enzymology; Hepacivirus - genetics; Hepatitis C; Hepatitis C - drug therapy; Hepatitis C - virology; Host-Pathogen Interactions - drug effects; Humanities and Social Sciences; Humans; Hydrolyzable Tannins - chemistry; Hydrolyzable Tannins - metabolism; Hydrolyzable Tannins - pharmacology; Liver diseases; Mass Spectrometry; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; multidisciplinary; Pharmacokinetics; Phytotherapy; Proteases; Protein Binding; Proteinase; Punica granatum; Punicaceae - chemistry; Replication; Science; Small Molecule Libraries - chemistry; Small Molecule Libraries - metabolism; Small Molecule Libraries - pharmacology; Viral Nonstructural Proteins - antagonists & inhibitors; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Virus Replication - drug effects

Hepatitis C virus (HCV) is the causative agent of end-stage liver disease. Recent advances in the last decade in anti HCV treatment strategies have dramatically increased the viral clearance rate. However, several limitations are still associated, which warrant a great need of novel, safe and select...