Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment
Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm -positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm -positive S. mut...
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| Published in | Scientific reports Vol. 6; no. 1; p. 38561 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
09.12.2016
Nature Publishing Group |
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| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/srep38561 |
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| Abstract | Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on
cnm
-positive
Streptococcus mutans
is involved in the development of CMBs. However, whether the collagen binding activity of
cnm
-positive
S. mutans
is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of
cnm
-positive
S. mutans
in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive
S. mutans
was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with
S. mutans
expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with
cnm
-positive
S. mutans
expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction. |
|---|---|
| AbstractList | Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on
cnm
-positive
Streptococcus mutans
is involved in the development of CMBs. However, whether the collagen binding activity of
cnm
-positive
S. mutans
is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of
cnm
-positive
S. mutans
in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive
S. mutans
was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with
S. mutans
expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with
cnm
-positive
S. mutans
expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction. Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive S. mutans was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with S. mutans expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction. |
| ArticleNumber | 38561 |
| Author | Matsui, Daisuke Takeda, Kazuo Tanaka, Tokutaro Friedland, Robert P. Iwai, Komei Nishigaki, Masaru Akazawa, Kentaro Ozaki, Etsuko Kuriyama, Nagato Nakano, Kazuhiko Kanamura, Narisato Ihara, Masafumi Nakagawa, Masanori Nomura, Ryota Watanabe, Isao Tamura, Aiko Mizuno, Toshiki Miyatani, Fumitaro Koyama, Teruhide Takada, Akihiro Yamamoto, Toshiro Watanabe, Yoshiyuki Yamada, Kei Naka, Shuhei |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27934941$$D View this record in MEDLINE/PubMed |
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| Snippet | Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on
cnm... Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on... |
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| SubjectTerms | 692/499 692/617 Cognitive ability Collagen Dementia Dementia disorders Humanities and Social Sciences multidisciplinary Polymerase chain reaction Risk factors Saliva Science Streptococcus Streptococcus infections Stroke |
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| Title | Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment |
| URI | https://link.springer.com/article/10.1038/srep38561 https://www.ncbi.nlm.nih.gov/pubmed/27934941 https://www.proquest.com/docview/1899373371 https://www.proquest.com/docview/1847891941 https://pubmed.ncbi.nlm.nih.gov/PMC5146923 |
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