Critical size dependence of domain formation observed in coarse-grained simulations of bilayers composed of ternary lipid mixtures

• Published in: The Journal of chemical physics Vol. 147; no. 9; pp. 095101 - 95109
• Main Authors: Pantelopulos, George A., Nagai, Tetsuro, Bandara, Asanga, Panahi, Afra, Straub, John E.
• Format: Journal Article
• Language: English
• Published: United States American Institute of Physics 07.09.2017; AIP Publishing LLC
• Subjects: 1,2-Dipalmitoylphosphatidylcholine - chemistry; Cell membranes; Cholesterol; Cholesterol - chemistry; Computer simulation; Dependence; Domains; Lipid Bilayers - chemistry; Lipids; Lipids - chemistry; Models, Chemical; Molecular Dynamics Simulation; Phase separation; Physics; Structure-Activity Relationship; Thermodynamics

Model cellular membranes are known to form micro- and macroscale lipid domains dependent on molecular composition. The formation of macroscopic lipid domains by lipid mixtures has been the subject of many simulation investigations. We present a critical study of system size impact on lipid domain ph...