Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma sa...
Saved in:
| Published in | Scientific reports Vol. 6; no. 1; p. 24316 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
18.04.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon
in vitro
mixing. This is the first study to show co-purification and
in vitro
association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL. |
|---|---|
| AbstractList | Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL. Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL. Abstract Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remains challenging. Here we studied human pre-prandial and 4 hours postprandial platelet-free blood plasma samples as well as human platelet concentrates. Using flow cytometry, we found that the majority of circulating particles within the size range of extracellular vesicles lacked common vesicular markers. We identified most of these particles as lipoproteins (predominantly low-density lipoprotein, LDL) which mimicked the characteristics of extracellular vesicles and also co-purified with them. Based on biophysical properties of LDL this finding was highly unexpected. Current state-of-the-art extracellular vesicle isolation and purification methods did not result in lipoprotein-free vesicle preparations from blood plasma or from platelet concentrates. Furthermore, transmission electron microscopy showed an association of LDL with isolated vesicles upon in vitro mixing. This is the first study to show co-purification and in vitro association of LDL with extracellular vesicles and its interference with vesicle analysis. Our data point to the importance of careful study design and data interpretation in studies using blood-derived extracellular vesicles with special focus on potentially co-purified LDL. |
| ArticleNumber | 24316 |
| Author | Falus, András Pállinger, Éva Buzás, Edit Irén Vukman, Krisztina V Drahos, László Giricz, Zoltán Vékey, Károly Szabó-Taylor, Katalin Pálóczi, Krisztina Wiener, Zoltán Sperlágh, Beáta Ferdinandy, Péter Németh, Andrea Turiák, Lilla Kittel, Ágnes Sódar, Barbara W Osteikoetxea, Xabier Baranyai, Tamás |
| Author_xml | – sequence: 1 givenname: Barbara W surname: Sódar fullname: Sódar, Barbara W organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 2 givenname: Ágnes surname: Kittel fullname: Kittel, Ágnes organization: Institute of Experimental Medicine, Hungarian Academy of Sciences – sequence: 3 givenname: Krisztina surname: Pálóczi fullname: Pálóczi, Krisztina organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 4 givenname: Krisztina V surname: Vukman fullname: Vukman, Krisztina V organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 5 givenname: Xabier surname: Osteikoetxea fullname: Osteikoetxea, Xabier organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 6 givenname: Katalin surname: Szabó-Taylor fullname: Szabó-Taylor, Katalin organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 7 givenname: Andrea surname: Németh fullname: Németh, Andrea organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 8 givenname: Beáta surname: Sperlágh fullname: Sperlágh, Beáta organization: Institute of Experimental Medicine, Hungarian Academy of Sciences – sequence: 9 givenname: Tamás surname: Baranyai fullname: Baranyai, Tamás organization: Department of Pharmacology and Pharmacotherapy, Semmelweis University – sequence: 10 givenname: Zoltán surname: Giricz fullname: Giricz, Zoltán organization: Department of Pharmacology and Pharmacotherapy, Semmelweis University – sequence: 11 givenname: Zoltán surname: Wiener fullname: Wiener, Zoltán organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 12 givenname: Lilla surname: Turiák fullname: Turiák, Lilla organization: Research Centre for Natural Sciences, Hungarian Academy of Sciences – sequence: 13 givenname: László surname: Drahos fullname: Drahos, László organization: Research Centre for Natural Sciences, Hungarian Academy of Sciences – sequence: 14 givenname: Éva surname: Pállinger fullname: Pállinger, Éva organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 15 givenname: Károly surname: Vékey fullname: Vékey, Károly organization: Research Centre for Natural Sciences, Hungarian Academy of Sciences – sequence: 16 givenname: Péter surname: Ferdinandy fullname: Ferdinandy, Péter organization: Department of Pharmacology and Pharmacotherapy, Semmelweis University – sequence: 17 givenname: András surname: Falus fullname: Falus, András organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University – sequence: 18 givenname: Edit Irén surname: Buzás fullname: Buzás, Edit Irén organization: Department of Genetics, Cell- and Immunobiology, Semmelweis University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27087061$$D View this record in MEDLINE/PubMed |
| BookMark | eNplkU1v1DAQhi1UREvpgT-AInEBpIDt-CuXSqgqH9JKXOBsOfakuHLsYCcL_ff1smW1gC9jzzx6ZzzvU3QSUwSEnhP8luBOvSsZZso6Ih6hM4oZb2lH6cnR_RRdlHKL6-G0Z6R_gk6pxEpiQc7QtEk_Wwex-OWuCX5Oc04L-NhMfvK2NENIyTVzMGUylct-C66BX6mkCUpjoqugzWkLxdtQM27NPt40vqRgFp_ib8TBAnb3eoYejyYUuHiI5-jbh-uvV5_azZePn6_eb1rLMVtaAYwIbh03jmBhRgzM1cAlI3QYOZfGcEGxGAfpaA8DF7ZzxoC0Q2-UVd05utzrzuswgbMQl2yCnrOfTL7TyXj9dyX67_ombTVTHeOcVoFXDwI5_VihLHryxUIIJkJaiyZSUUqk7LuKvvwHvU1rjvV7mqheCYVlLyv1ek_VZZVq2XgYhmC981EffKzsi-PpD-Qf1yrwZg-UebdtyEct_1O7B5NerHk |
| CitedBy_id | crossref_primary_10_3390_bios13070688 crossref_primary_10_1039_C9LC00902G crossref_primary_10_1089_ars_2017_7265 crossref_primary_10_1172_jci_insight_137937 crossref_primary_10_1016_j_theriogenology_2023_04_010 crossref_primary_10_2174_1381612826666200420144805 crossref_primary_10_1016_j_ejps_2016_10_008 crossref_primary_10_3390_ijms25105543 crossref_primary_10_1038_s41598_018_23505_0 crossref_primary_10_3390_cells13080702 crossref_primary_10_3390_ijms22083839 crossref_primary_10_3390_nano11061476 crossref_primary_10_1038_s41598_017_05787_y crossref_primary_10_1096_fj_201700488r crossref_primary_10_1016_j_virol_2019_12_010 crossref_primary_10_1016_j_aca_2019_07_035 crossref_primary_10_1016_j_atherosclerosis_2020_11_006 crossref_primary_10_1038_s41598_019_52366_4 crossref_primary_10_1186_s13024_021_00470_3 crossref_primary_10_1016_j_bbcan_2018_11_006 crossref_primary_10_1177_2472630319846877 crossref_primary_10_1186_s12951_020_00722_2 crossref_primary_10_2217_nnm_2018_0287 crossref_primary_10_3389_fimmu_2022_822995 crossref_primary_10_1080_20013078_2018_1555419 crossref_primary_10_1002_smll_202307240 crossref_primary_10_1101_cshperspect_a041415 crossref_primary_10_1080_20013078_2019_1710020 crossref_primary_10_3390_nano11061481 crossref_primary_10_1002_jev2_12349 crossref_primary_10_1002_jev2_12348 crossref_primary_10_1016_j_chroma_2023_464293 crossref_primary_10_1021_acsomega_3c07427 crossref_primary_10_1088_2516_1091_ac73c9 crossref_primary_10_1080_14712598_2020_1813276 crossref_primary_10_1016_j_biopha_2023_115229 crossref_primary_10_1039_D1NR03334D crossref_primary_10_1002_jnr_23899 crossref_primary_10_1111_trf_17593 crossref_primary_10_1080_20013078_2019_1588538 crossref_primary_10_1002_adbi_201900310 crossref_primary_10_1080_20013078_2020_1764213 crossref_primary_10_3390_jcm11123431 crossref_primary_10_1016_j_ejcb_2022_151227 crossref_primary_10_1002_term_3155 crossref_primary_10_1038_s42003_021_01882_z crossref_primary_10_3390_nu16050736 crossref_primary_10_1016_j_bbi_2020_12_007 crossref_primary_10_1016_j_colsurfb_2017_06_047 crossref_primary_10_1021_acsomega_9b00966 crossref_primary_10_1093_jxb_erac512 crossref_primary_10_1016_j_gene_2023_147905 crossref_primary_10_1152_japplphysiol_00914_2018 crossref_primary_10_1186_s12885_017_3737_z crossref_primary_10_1002_jex2_49 crossref_primary_10_1039_D2RA02351B crossref_primary_10_1016_j_biotechadv_2021_107814 crossref_primary_10_1080_20013078_2017_1407213 crossref_primary_10_3390_ijms22042158 crossref_primary_10_1113_JP278929 crossref_primary_10_3390_cells10123473 crossref_primary_10_1038_s41598_021_83132_0 crossref_primary_10_1016_j_addr_2023_115054 crossref_primary_10_3390_ijms241210162 crossref_primary_10_1016_j_jtha_2023_01_007 crossref_primary_10_1002_jev2_12369 crossref_primary_10_1186_s13287_019_1215_z crossref_primary_10_1002_jev2_12128 crossref_primary_10_1021_acsbiomaterials_1c01226 crossref_primary_10_1038_s41598_020_78422_y crossref_primary_10_1042_CS20200892 crossref_primary_10_1371_journal_pone_0236508 crossref_primary_10_3390_ijms21176373 crossref_primary_10_1016_j_seppur_2023_126155 crossref_primary_10_1155_2017_9653194 crossref_primary_10_3390_ijms23179619 crossref_primary_10_1007_s00018_019_03052_1 crossref_primary_10_3233_CBM_170955 crossref_primary_10_1002_adhm_202400293 crossref_primary_10_1007_s00018_020_03703_8 crossref_primary_10_1002_jev2_12376 crossref_primary_10_1002_jev2_12256 crossref_primary_10_3390_biom14060727 crossref_primary_10_1002_elps_202000223 crossref_primary_10_33549_physiolres_934886 crossref_primary_10_1002_elps_202100234 crossref_primary_10_1093_biolre_ioaa019 crossref_primary_10_1186_s12943_023_01741_x crossref_primary_10_3390_proteomes10020019 crossref_primary_10_1038_s41598_022_17944_z crossref_primary_10_3390_pharmaceutics11110557 crossref_primary_10_3892_ijo_2022_5423 crossref_primary_10_1186_s12964_024_01707_6 crossref_primary_10_1007_s11427_020_1905_7 crossref_primary_10_1146_annurev_biochem_013118_111902 crossref_primary_10_1080_20013078_2019_1670935 crossref_primary_10_3390_ijms20061259 crossref_primary_10_1097_BOR_0000000000000483 crossref_primary_10_3389_fcell_2020_00367 crossref_primary_10_12688_f1000research_14129_3 crossref_primary_10_1021_acs_analchem_0c01986 crossref_primary_10_1186_s12964_023_01126_z crossref_primary_10_1080_20013078_2018_1560809 crossref_primary_10_1016_j_ymthe_2024_02_019 crossref_primary_10_1080_20013078_2018_1560808 crossref_primary_10_1007_s12079_019_00524_8 crossref_primary_10_1371_journal_pone_0262484 crossref_primary_10_1161_CIRCRESAHA_117_311767 crossref_primary_10_1016_j_cca_2019_03_1621 crossref_primary_10_1111_tra_12803 crossref_primary_10_3390_cancers13143414 crossref_primary_10_1080_20013078_2019_1696517 crossref_primary_10_1016_j_cytogfr_2023_12_004 crossref_primary_10_1016_j_jhep_2020_07_014 crossref_primary_10_1007_s00018_018_2773_4 crossref_primary_10_1038_s41598_017_02908_5 crossref_primary_10_3390_ijms21155359 crossref_primary_10_1002_jev2_12260 crossref_primary_10_1002_jev2_12140 crossref_primary_10_1016_j_gene_2020_145379 crossref_primary_10_1161_CIRCRESAHA_117_309417 crossref_primary_10_1111_nph_16725 crossref_primary_10_1002_jev2_12021 crossref_primary_10_1016_j_yjmcc_2017_03_005 crossref_primary_10_3390_diagnostics10110943 crossref_primary_10_3389_fmed_2020_616578 crossref_primary_10_1093_cvr_cvx211 crossref_primary_10_1016_j_tibtech_2020_05_012 crossref_primary_10_1016_j_tcb_2023_01_002 crossref_primary_10_1186_s43556_020_00002_3 crossref_primary_10_1371_journal_ppat_1011052 crossref_primary_10_1093_cvr_cvac031 crossref_primary_10_1007_s11154_021_09680_y crossref_primary_10_1016_j_omtn_2022_06_008 crossref_primary_10_1002_ijc_33386 crossref_primary_10_3389_fimmu_2022_949670 crossref_primary_10_1016_j_colsurfb_2023_113704 crossref_primary_10_1002_sctm_17_0081 crossref_primary_10_1002_jev2_12270 crossref_primary_10_3402_jev_v5_32945 crossref_primary_10_1002_jev2_12033 crossref_primary_10_1186_s12885_021_08870_w crossref_primary_10_1016_j_micron_2024_103662 crossref_primary_10_1021_acs_analchem_9b04198 crossref_primary_10_1063_10_0020885 crossref_primary_10_3390_ijms22010048 crossref_primary_10_1007_s00018_017_2535_8 crossref_primary_10_1016_j_isci_2024_109359 crossref_primary_10_1186_s12967_017_1374_6 crossref_primary_10_3390_ijms22168430 crossref_primary_10_1016_j_semcancer_2021_05_011 crossref_primary_10_1016_j_snb_2020_128056 crossref_primary_10_1021_acsnano_3c01340 crossref_primary_10_3390_biology12091233 crossref_primary_10_1021_acsnano_7b07782 crossref_primary_10_1021_acs_nanolett_3c03579 crossref_primary_10_1021_acsnano_7b08199 crossref_primary_10_1093_genetics_iyae088 crossref_primary_10_18097_PBMC20176301091 crossref_primary_10_1080_21655979_2021_2006866 crossref_primary_10_1039_C7NR08360B crossref_primary_10_1002_jev2_12044 crossref_primary_10_1111_acel_13103 crossref_primary_10_1002_jev2_12299 crossref_primary_10_1002_pmic_202300063 crossref_primary_10_1002_pmic_202300062 crossref_primary_10_1016_j_cellsig_2020_109751 crossref_primary_10_1111_jth_14193 crossref_primary_10_1002_cyto_a_24036 crossref_primary_10_1007_s40291_020_00493_4 crossref_primary_10_1038_s41598_020_80514_8 crossref_primary_10_1039_D1MA00273B crossref_primary_10_3390_ijms21186466 crossref_primary_10_3389_fchem_2019_00279 crossref_primary_10_3390_diagnostics11061118 crossref_primary_10_1016_j_jconrel_2020_10_020 crossref_primary_10_3389_fcvm_2018_00172 crossref_primary_10_1016_j_phrs_2021_105868 crossref_primary_10_1002_pmic_201800162 crossref_primary_10_1016_j_biochi_2021_10_009 crossref_primary_10_1016_j_jddst_2023_104796 crossref_primary_10_1021_acsami_2c07143 crossref_primary_10_1016_j_jtha_2024_01_010 crossref_primary_10_3390_ijms23074005 crossref_primary_10_3389_fbioe_2020_624096 crossref_primary_10_3390_biomedicines9020124 crossref_primary_10_1002_jev2_12177 crossref_primary_10_1007_s10741_021_10084_y crossref_primary_10_1021_acs_jproteome_1c00549 crossref_primary_10_1002_pmic_202000211 crossref_primary_10_1080_20013078_2019_1565263 crossref_primary_10_1002_cbin_11620 crossref_primary_10_1016_j_prp_2019_152574 crossref_primary_10_3389_fimmu_2024_1343364 crossref_primary_10_3390_ijms232416111 crossref_primary_10_1124_dmd_121_000411 crossref_primary_10_3390_ijms20235995 crossref_primary_10_1186_s12929_019_0502_4 crossref_primary_10_1134_S1990750817030040 crossref_primary_10_1016_j_addr_2020_08_003 crossref_primary_10_1038_s41598_017_01386_z crossref_primary_10_1002_bmm2_12018 crossref_primary_10_1016_j_aca_2020_05_031 crossref_primary_10_1016_j_bbalip_2020_158855 crossref_primary_10_1080_20013078_2019_1615820 crossref_primary_10_1021_acsnano_6b05630 crossref_primary_10_1007_s10911_020_09473_0 crossref_primary_10_1016_j_biomaterials_2018_10_045 crossref_primary_10_1016_j_expneurol_2022_114149 crossref_primary_10_1039_D0BM01801E crossref_primary_10_1016_j_ymeth_2016_09_018 crossref_primary_10_1080_20013078_2018_1508271 crossref_primary_10_1371_journal_pone_0270634 crossref_primary_10_1016_j_bbrc_2018_03_107 crossref_primary_10_1007_s10571_019_00684_6 crossref_primary_10_1007_s10557_016_6698_6 crossref_primary_10_1080_20013078_2018_1535750 crossref_primary_10_3390_metabo9110259 crossref_primary_10_1021_acs_jafc_3c06867 crossref_primary_10_1002_cbin_12014 crossref_primary_10_1016_j_aca_2021_338578 crossref_primary_10_1016_j_molmed_2022_05_003 crossref_primary_10_1007_s00216_022_04174_5 crossref_primary_10_1007_s00395_020_0785_3 crossref_primary_10_7554_eLife_86394 crossref_primary_10_3904_kjim_2019_108 crossref_primary_10_1002_jev2_12404 crossref_primary_10_1002_admt_201900539 crossref_primary_10_1158_1078_0432_CCR_18_2946 crossref_primary_10_1080_20013078_2019_1697028 crossref_primary_10_1016_j_aca_2024_342473 crossref_primary_10_1371_journal_pone_0285440 crossref_primary_10_3390_cimb46050264 crossref_primary_10_5483_BMBRep_2022_55_1_161 crossref_primary_10_1007_s00018_021_03969_6 crossref_primary_10_1080_14686996_2022_2133342 crossref_primary_10_1016_j_mam_2017_11_004 crossref_primary_10_1016_j_bios_2020_112622 crossref_primary_10_1016_j_exger_2023_112142 crossref_primary_10_1016_j_bbalip_2020_158634 crossref_primary_10_1016_j_plipres_2017_03_001 crossref_primary_10_1080_20013078_2017_1286095 crossref_primary_10_1016_j_omtn_2022_08_032 crossref_primary_10_1007_s00018_023_04889_3 crossref_primary_10_3402_jev_v5_31803 crossref_primary_10_1002_pmic_202300078 crossref_primary_10_1098_rstb_2016_0480 crossref_primary_10_1080_09537104_2017_1280602 crossref_primary_10_1002_jex2_68 crossref_primary_10_1002_jex2_147 crossref_primary_10_1080_0284186X_2018_1551621 crossref_primary_10_1007_s00018_019_03071_y crossref_primary_10_1186_s13287_022_02912_1 crossref_primary_10_3390_ijms21207687 crossref_primary_10_1002_jex2_66 crossref_primary_10_1038_s41392_020_00258_9 crossref_primary_10_1080_14737159_2019_1657407 crossref_primary_10_1016_j_freeradbiomed_2017_03_016 crossref_primary_10_2217_nnm_2016_0192 crossref_primary_10_1080_15622975_2023_2197039 crossref_primary_10_2147_IJN_S283106 crossref_primary_10_1021_acs_analchem_6b01694 crossref_primary_10_1160_TH16_12_0943 crossref_primary_10_3390_ijms19092822 crossref_primary_10_3390_proteomes7020022 crossref_primary_10_1002_INMD_20220003 crossref_primary_10_1002_jev2_12090 crossref_primary_10_1080_20013078_2019_1625677 crossref_primary_10_3389_fbioe_2022_1032318 crossref_primary_10_3390_biomedicines10040783 crossref_primary_10_18632_oncotarget_20748 crossref_primary_10_1021_acs_analchem_1c05378 crossref_primary_10_3389_fphys_2020_579892 crossref_primary_10_1002_jex2_138 crossref_primary_10_3390_ijms22041729 crossref_primary_10_1080_09537104_2016_1260704 crossref_primary_10_1186_s12943_021_01396_6 crossref_primary_10_3389_fphys_2020_576150 crossref_primary_10_1002_mas_21738 crossref_primary_10_1002_advs_202400533 crossref_primary_10_1016_j_omtm_2020_07_012 crossref_primary_10_1080_20013078_2020_1791450 crossref_primary_10_1080_20013078_2019_1582237 crossref_primary_10_3390_ijms222413540 crossref_primary_10_3390_ijms231810390 crossref_primary_10_1186_s12943_018_0772_6 crossref_primary_10_3390_cells10092221 crossref_primary_10_3390_ijms22094653 crossref_primary_10_7554_eLife_70725 crossref_primary_10_3390_jcm11102832 crossref_primary_10_1007_s00395_021_00856_w crossref_primary_10_1152_ajpregu_00220_2021 crossref_primary_10_1016_j_cytogfr_2023_08_003 crossref_primary_10_1007_s00281_018_0682_0 crossref_primary_10_1111_jth_14154 crossref_primary_10_3390_cancers12092335 crossref_primary_10_1002_jex2_85 crossref_primary_10_1080_20013078_2017_1388731 crossref_primary_10_1161_CIRCRESAHA_117_311215 crossref_primary_10_1021_acs_analchem_9b05675 crossref_primary_10_1038_s41413_023_00313_5 crossref_primary_10_1080_20013078_2019_1599682 crossref_primary_10_1038_s41598_021_84234_5 crossref_primary_10_1016_j_jconrel_2019_06_006 crossref_primary_10_1042_CS20220150 crossref_primary_10_1016_j_cca_2019_05_028 crossref_primary_10_2147_IJN_S328325 crossref_primary_10_1016_j_pneurobio_2019_01_005 crossref_primary_10_1080_20013078_2017_1308779 crossref_primary_10_1186_s40104_022_00715_1 crossref_primary_10_1021_acs_jproteome_8b00225 crossref_primary_10_3390_cancers13112792 crossref_primary_10_1371_journal_pone_0170628 crossref_primary_10_1515_cclm_2018_1048 crossref_primary_10_1016_j_bbalip_2017_09_012 crossref_primary_10_1038_s41598_018_35401_8 crossref_primary_10_1016_j_micron_2022_103341 crossref_primary_10_1002_jex2_120 crossref_primary_10_1002_jex2_91 crossref_primary_10_1002_jev2_12202 crossref_primary_10_1002_pul2_12014 crossref_primary_10_1038_s41565_023_01522_z crossref_primary_10_1002_jev2_12200 crossref_primary_10_1038_s41596_021_00551_z crossref_primary_10_1002_jev2_12208 crossref_primary_10_1194_jlr_R084343 crossref_primary_10_1007_s00281_018_0678_9 crossref_primary_10_1080_20013078_2018_1481321 crossref_primary_10_3389_fphys_2018_01479 crossref_primary_10_1016_j_critrevonc_2024_104341 crossref_primary_10_1038_s41598_020_57497_7 crossref_primary_10_1152_ajpendo_00062_2020 crossref_primary_10_3390_proteomes7020018 crossref_primary_10_1007_s10571_020_00905_3 crossref_primary_10_1016_j_addr_2020_03_002 crossref_primary_10_1039_D1AN00373A crossref_primary_10_3390_cancers15051579 crossref_primary_10_3389_fphar_2021_773844 crossref_primary_10_1016_j_aca_2024_342959 crossref_primary_10_3390_biom9110666 crossref_primary_10_1039_D0NA00676A crossref_primary_10_2147_IJN_S303391 |
| Cites_doi | 10.1111/j.1538-7836.2012.04683.x 10.1002/cbic.201400043 10.1242/jcs.128868 10.1016/j.jprot.2011.01.007 10.1016/S0956-5663(01)00235-4 10.1160/Th13-02-0178 10.1038/nrrheum.2014.19 10.1016/j.jacc.2014.05.015 10.1016/0021-9150(80)90065-9 10.1038/nature14581 10.1182/blood-2010-09-307595 10.1146/annurev-cellbio-101512-122326 10.1016/j.thromres.2013.11.010 10.1515/cclm-2013-0358 10.1016/j.celrep.2015.08.057 10.1039/c5ob01451d 10.3390/ijms150915530 10.1016/j.jacl.2007.10.001 10.1016/j.jprot.2011.05.023 10.1016/j.jprot.2014.04.030 10.1152/ajpcell.00308.2005 10.1007/s00018-011-0689-3 10.1111/jth.12207 10.1006/bbrc.1995.2651 10.1002/pmic.201300282 10.1038/nm.2753 10.4049/jimmunol.171.6.3025 10.1038/nri2567 10.1007/s00018-014-1618-z 10.1515/bmc-2013-0016 10.3402/jev.v3.24858 10.1016/S0022-2275(20)43118-9 10.3402/jev.v3.24692 10.1371/journal.pone.0121184 10.1095/biolreprod.113.113266 10.1016/S0022-2275(20)38212-2 10.3402/jev.v3.23430 10.14814/phy2.12018 10.1371/journal.pone.0049726 10.1186/1476-511X-12-179 10.1016/S0167-7306(02)36020-4 10.1093/clinchem/46.10.1638 10.3402/jev.v3.23262 10.1016/S0022-2275(20)41124-1 10.3402/jev.v2i0.20360 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2016 Copyright Nature Publishing Group Apr 2016 Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited |
| Copyright_xml | – notice: The Author(s) 2016 – notice: Copyright Nature Publishing Group Apr 2016 – notice: Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited |
| DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI Q9U 7X8 5PM |
| DOI | 10.1038/srep24316 |
| DatabaseName | Springer Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Science Journals Biological Science Database Access via ProQuest (Open Access) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Publicly Available Content Database MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Open Access url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 24316 |
| ExternalDocumentID | 10_1038_srep24316 27087061 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP CGR CUY CVF ECM EIF NPM AAYXX AFPKN CITATION 7XB 8FK K9. PQEST PQUKI Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c504t-6e4165cd5ad106af0e4d6af57412bf557aa56206fb7d29eb56c3daae7cb9a8c83 |
| IEDL.DBID | RPM |
| ISSN | 2045-2322 |
| IngestDate | Tue Sep 17 21:27:55 EDT 2024 Fri Oct 25 05:14:30 EDT 2024 Sat Nov 09 13:23:09 EST 2024 Fri Aug 23 03:29:27 EDT 2024 Tue Oct 15 23:55:15 EDT 2024 Fri Oct 11 20:55:29 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c504t-6e4165cd5ad106af0e4d6af57412bf557aa56206fb7d29eb56c3daae7cb9a8c83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834552/ |
| PMID | 27087061 |
| PQID | 1898680797 |
| PQPubID | 2041939 |
| PageCount | 1 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4834552 proquest_miscellaneous_1782217793 proquest_journals_1898680797 crossref_primary_10_1038_srep24316 pubmed_primary_27087061 springer_journals_10_1038_srep24316 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-04-18 |
| PublicationDateYYYYMMDD | 2016-04-18 |
| PublicationDate_xml | – month: 04 year: 2016 text: 2016-04-18 day: 18 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2016 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Liu (CR38) 2006; 290 Liao, Liu, Yin, Pu (CR37) 2014; 15 Gyorgy (CR19) 2011; 117 Millar (CR30) 1995; 36 CR16 CR14 CR36 Kalra (CR39) 2013; 13 Gyorgy (CR2) 2011; 68 CR12 Osteikoetxea (CR23) 2015; 13 Siegel, Malmsten, Klussendorf, Michel (CR34) 2001; 16 Aviram (CR17) 1995; 216 CR10 CR32 Melo (CR7) 2015; 523 Colombo (CR4) 2013; 126 Gyorgy (CR11) 2014; 133 Thery, Ostrowski, Segura (CR1) 2009; 9 Cromwell (CR26) 2007; 1 Buzas, Gyorgy, Nagy, Falus, Gay (CR8) 2014; 10 Turiak, Ozohanics, Marino, Drahos, Vekey (CR48) 2011; 74 Anderson, Boyles, Hussain (CR28) 1989; 30 Buzas (CR43) 2003; 171 Salpeter, Zilversmit (CR22) 1968; 9 CR6 CR5 Turiak (CR44) 2011; 74 Colombo, Raposo, Thery (CR3) 2014; 30 van Niel (CR21) 2015; 13 CR29 Kastelowitz, Yin (CR35) 2014; 15 Lu, Gursky (CR18) 2013; 4 Dashty (CR40) 2014; 111 Morris, Ballantyne, Birtcher, Dunn, Urbina (CR15) 2014; 64 CR47 Ramasamy (CR13) 2014; 52 CR24 Peinado (CR9) 2012; 18 CR45 Van der Pol, Van Gemert, Sturk, Nieuwland, Van Leeuwen (CR27) 2012; 10 CR20 Smith, Staples (CR25) 1980; 37 CR42 von Zychlinski, Williams, McCormick, Kleffmann (CR33) 2014; 106 Szabo (CR46) 2014; 71 Lorec (CR31) 2000; 46 Lacroix (CR41) 2013; 11 24227753 - Biol Reprod. 2013 Dec;89(6):151 24500811 - Thromb Haemost. 2014 Mar 3;111(3):518-30 26106858 - Nature. 2015 Jul 9;523(7559):177-82 25279113 - J Extracell Vesicles. 2014 Sep 08;3:null 24360116 - Thromb Res. 2014 Feb;133(2):285-92 24314230 - Lipids Health Dis. 2013;12:179 25317274 - J Extracell Vesicles. 2014 Sep 18;3:null 23940067 - Clin Chem Lab Med. 2014 Dec;52(12):1695-727 23185418 - PLoS One. 2012;7(11):e49726 24907293 - Physiol Rep. 2014 Jun 06;2(6):null 21560073 - Cell Mol Life Sci. 2011 Aug;68(16):2667-88 25147646 - J Extracell Vesicles. 2014 Aug 06;3:null 24780726 - J Proteomics. 2014 Jun 25;106:181-90 24893313 - PLoS Biol. 2014 Jun;12(6):e1001874 2482323 - J Lipid Res. 1989 Nov;30(11):1819-24 25184951 - Int J Mol Sci. 2014;15(9):15530-51 24105262 - J Cell Sci. 2013 Dec 15;126(Pt 24):5553-65 25197325 - Biomol Concepts. 2013 Oct;4(5):501-18 26387950 - Cell Rep. 2015 Oct 6;13(1):43-51 23551930 - J Thromb Haemost. 2013 Apr 2;:null 24740901 - Chembiochem. 2014 May 5;15(7):923-8 5640498 - J Lipid Res. 1968 Mar;9(2):187-92 11017943 - Clin Chem. 2000 Oct;46(10):1638-42 21635979 - J Proteomics. 2011 Sep 6;74(10):2025-33 21041717 - Blood. 2011 Jan 27;117(4):e39-48 25288114 - Annu Rev Cell Dev Biol. 2014;30:255-89 25798862 - PLoS One. 2015;10(3):e0121184 25018865 - J Extracell Vesicles. 2014 Jul 08;3:null 16282196 - Am J Physiol Cell Physiol. 2006 Apr;290(4):C990-9 25979354 - J Extracell Vesicles. 2015 May 14;4:27066 24535546 - Nat Rev Rheumatol. 2014 Jun;10(6):356-64 24009894 - J Extracell Vesicles. 2013 May 27;2:null 19657464 - J Clin Lipidol. 2007 Dec;1(6):583-92 24115447 - Proteomics. 2013 Nov;13(22):3354-64 25011724 - J Am Coll Cardiol. 2014 Jul 15;64(2):196-206 11679268 - Biosens Bioelectron. 2001 Dec;16(9-12):895-904 12960328 - J Immunol. 2003 Sep 15;171(6):3025-33 7488140 - Biochem Biophys Res Commun. 1995 Nov 13;216(2):501-13 22394434 - J Thromb Haemost. 2012 May;10(5):919-30 21256993 - J Proteomics. 2011 Jun 10;74(7):942-7 26264754 - Org Biomol Chem. 2015 Oct 14;13(38):9775-82 22635005 - Nat Med. 2012 Jun;18(6):883-91 6161619 - Atherosclerosis. 1980 Dec;37(4):579-90 7665994 - J Lipid Res. 1995 Jun;36(6):1155-67 24705984 - Cell Mol Life Sci. 2014 Oct;71(20):4055-67 19498381 - Nat Rev Immunol. 2009 Aug;9(8):581-93 BFsrep24316_CR10 BFsrep24316_CR32 M Aviram (BFsrep24316_CR17) 1995; 216 M Dashty (BFsrep24316_CR40) 2014; 111 BFsrep24316_CR12 X Osteikoetxea (BFsrep24316_CR23) 2015; 13 M Colombo (BFsrep24316_CR4) 2013; 126 M Colombo (BFsrep24316_CR3) 2014; 30 EB Smith (BFsrep24316_CR25) 1980; 37 AM Lorec (BFsrep24316_CR31) 2000; 46 B Gyorgy (BFsrep24316_CR11) 2014; 133 H Kalra (BFsrep24316_CR39) 2013; 13 BFsrep24316_CR14 BFsrep24316_CR36 B Gyorgy (BFsrep24316_CR2) 2011; 68 BFsrep24316_CR16 MM Salpeter (BFsrep24316_CR22) 1968; 9 SG Liu (BFsrep24316_CR38) 2006; 290 G Siegel (BFsrep24316_CR34) 2001; 16 LJ Anderson (BFsrep24316_CR28) 1989; 30 L Turiak (BFsrep24316_CR48) 2011; 74 M Lu (BFsrep24316_CR18) 2013; 4 B Gyorgy (BFsrep24316_CR19) 2011; 117 GT Szabo (BFsrep24316_CR46) 2014; 71 C Thery (BFsrep24316_CR1) 2009; 9 G van Niel (BFsrep24316_CR21) 2015; 13 JS Millar (BFsrep24316_CR30) 1995; 36 BFsrep24316_CR20 BFsrep24316_CR42 E Van der Pol (BFsrep24316_CR27) 2012; 10 J Liao (BFsrep24316_CR37) 2014; 15 BFsrep24316_CR45 BFsrep24316_CR29 N Kastelowitz (BFsrep24316_CR35) 2014; 15 BFsrep24316_CR5 BFsrep24316_CR47 I Ramasamy (BFsrep24316_CR13) 2014; 52 BFsrep24316_CR24 EI Buzas (BFsrep24316_CR43) 2003; 171 L Turiak (BFsrep24316_CR44) 2011; 74 R Lacroix (BFsrep24316_CR41) 2013; 11 H Peinado (BFsrep24316_CR9) 2012; 18 WC Cromwell (BFsrep24316_CR26) 2007; 1 BFsrep24316_CR6 PB Morris (BFsrep24316_CR15) 2014; 64 SA Melo (BFsrep24316_CR7) 2015; 523 A von Zychlinski (BFsrep24316_CR33) 2014; 106 EI Buzas (BFsrep24316_CR8) 2014; 10 |
| References_xml | – ident: CR45 – volume: 10 start-page: 919 year: 2012 end-page: 930 ident: CR27 article-title: Single vs. swarm detection of microparticles and exosomes by flow cytometry publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2012.04683.x contributor: fullname: Van Leeuwen – volume: 15 start-page: 923 year: 2014 end-page: 928 ident: CR35 article-title: Exosomes and Microvesicles: Identification and Targeting By Particle Size and Lipid Chemical Probes publication-title: Chembiochem doi: 10.1002/cbic.201400043 contributor: fullname: Yin – ident: CR47 – volume: 126 start-page: 5553 year: 2013 end-page: 5565 ident: CR4 article-title: Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles publication-title: J Cell Sci doi: 10.1242/jcs.128868 contributor: fullname: Colombo – volume: 74 start-page: 942 year: 2011 end-page: 947 ident: CR48 article-title: Digestion protocol for small protein amounts for nano-HPLC-MS(MS) analysis publication-title: J Proteomics doi: 10.1016/j.jprot.2011.01.007 contributor: fullname: Vekey – ident: CR14 – ident: CR16 – volume: 16 start-page: 895 year: 2001 end-page: 904 ident: CR34 article-title: A receptor-based biosensor for lipoprotein docking at the endothelial surface and vascular matrix publication-title: Biosens Bioelectron doi: 10.1016/S0956-5663(01)00235-4 contributor: fullname: Michel – ident: CR12 – volume: 111 start-page: 518 year: 2014 end-page: 530 ident: CR40 article-title: Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism publication-title: Thromb Haemostasis doi: 10.1160/Th13-02-0178 contributor: fullname: Dashty – ident: CR10 – ident: CR6 – ident: CR29 – volume: 10 start-page: 356 year: 2014 end-page: 364 ident: CR8 article-title: Emerging role of extracellular vesicles in inflammatory diseases publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2014.19 contributor: fullname: Gay – volume: 64 start-page: 196 year: 2014 end-page: 206 ident: CR15 article-title: Review of Clinical Practice Guidelines for the Management of LDL-Related Risk publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2014.05.015 contributor: fullname: Urbina – volume: 9 start-page: 187 year: 1968 end-page: 192 ident: CR22 article-title: The surface coat of chylomicrons: electron microscopy publication-title: J Lipid Res contributor: fullname: Zilversmit – volume: 37 start-page: 579 year: 1980 end-page: 590 ident: CR25 article-title: Distribution of Plasma-Proteins across the Human Aortic-Wall - Barrier Functions of Endothelium and Internal Elastic Lamina publication-title: Atherosclerosis doi: 10.1016/0021-9150(80)90065-9 contributor: fullname: Staples – volume: 523 start-page: 177 year: 2015 end-page: U182 ident: CR7 article-title: Glypican-1 identifies cancer exosomes and detects early pancreatic cancer publication-title: Nature doi: 10.1038/nature14581 contributor: fullname: Melo – ident: CR42 – volume: 117 start-page: e39 year: 2011 end-page: 48 ident: CR19 article-title: Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters publication-title: Blood doi: 10.1182/blood-2010-09-307595 contributor: fullname: Gyorgy – volume: 30 start-page: 1819 year: 1989 end-page: 1824 ident: CR28 article-title: A Rapid Method for Staining Large Chylomicrons publication-title: Journal of Lipid Research contributor: fullname: Hussain – volume: 30 start-page: 255 year: 2014 end-page: 289 ident: CR3 article-title: Biogenesis, Secretion and Intercellular Interactions of Exosomes and Other Extracellular Vesicles publication-title: Annu Rev Cell Dev Bi doi: 10.1146/annurev-cellbio-101512-122326 contributor: fullname: Thery – volume: 133 start-page: 285 year: 2014 end-page: 292 ident: CR11 article-title: Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube publication-title: Thromb Res doi: 10.1016/j.thromres.2013.11.010 contributor: fullname: Gyorgy – volume: 52 start-page: 1695 year: 2014 end-page: 1727 ident: CR13 article-title: Recent advances in physiological lipoprotein metabolism publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2013-0358 contributor: fullname: Ramasamy – volume: 13 start-page: 43 year: 2015 end-page: 51 ident: CR21 article-title: Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells publication-title: Cell Rep doi: 10.1016/j.celrep.2015.08.057 contributor: fullname: van Niel – volume: 13 start-page: 9775 year: 2015 end-page: 9782 ident: CR23 article-title: Differential detergent sensitivity of extracellular vesicle subpopulations publication-title: Org Biomol Chem doi: 10.1039/c5ob01451d contributor: fullname: Osteikoetxea – volume: 15 start-page: 15530 year: 2014 end-page: 15551 ident: CR37 article-title: Expression Profiling of Exosomal miRNAs Derived from Human Esophageal Cancer Cells by Solexa High-Throughput Sequencing publication-title: Int J Mol Sci doi: 10.3390/ijms150915530 contributor: fullname: Pu – volume: 1 start-page: 583 year: 2007 end-page: 592 ident: CR26 article-title: LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2007.10.001 contributor: fullname: Cromwell – volume: 74 start-page: 2025 year: 2011 end-page: 2033 ident: CR44 article-title: Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice publication-title: J Proteomics doi: 10.1016/j.jprot.2011.05.023 contributor: fullname: Turiak – volume: 106 start-page: 181 year: 2014 end-page: 190 ident: CR33 article-title: Absolute quantification of apolipoproteins and associated proteins on human plasma lipoproteins publication-title: J Proteomics doi: 10.1016/j.jprot.2014.04.030 contributor: fullname: Kleffmann – volume: 36 start-page: 1155 year: 1995 end-page: 1167 ident: CR30 article-title: Impact of Age on the Metabolism of Vldl, Idl and Ldl Apolipoprotein B-100 in Men publication-title: Journal of Lipid Research contributor: fullname: Millar – volume: 290 start-page: C990 year: 2006 end-page: C999 ident: CR38 article-title: HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers publication-title: Am J Physiol-Cell Ph doi: 10.1152/ajpcell.00308.2005 contributor: fullname: Liu – volume: 46 start-page: 1638 year: 2000 end-page: 1642 ident: CR31 article-title: Determination of apolipoprotein B-48 in plasma by a competitive ELISA publication-title: Clin Chem contributor: fullname: Lorec – volume: 68 start-page: 2667 year: 2011 end-page: 2688 ident: CR2 article-title: Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles publication-title: Cell Mol Life Sci doi: 10.1007/s00018-011-0689-3 contributor: fullname: Gyorgy – volume: 11 start-page: 1190 year: 2013 end-page: 1193 ident: CR41 article-title: Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop publication-title: J Thromb Haemost doi: 10.1111/jth.12207 contributor: fullname: Lacroix – volume: 216 start-page: 501 year: 1995 end-page: 513 ident: CR17 article-title: Lesioned Low-Density-Lipoprotein in Atherosclerotic Apolipoprotein E-Deficient Transgenic Mice and in Humans Is Oxidized and Aggregated publication-title: Biochem Bioph Res Co doi: 10.1006/bbrc.1995.2651 contributor: fullname: Aviram – volume: 13 start-page: 3354 year: 2013 end-page: 3364 ident: CR39 article-title: Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma publication-title: Proteomics doi: 10.1002/pmic.201300282 contributor: fullname: Kalra – volume: 18 start-page: 883 year: 2012 ident: CR9 article-title: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET publication-title: Nat Med doi: 10.1038/nm.2753 contributor: fullname: Peinado – ident: CR32 – ident: CR36 – ident: CR5 – volume: 171 start-page: 3025 year: 2003 end-page: 3033 ident: CR43 article-title: Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones publication-title: J Immunol doi: 10.4049/jimmunol.171.6.3025 contributor: fullname: Buzas – volume: 9 start-page: 581 year: 2009 end-page: 593 ident: CR1 article-title: Membrane vesicles as conveyors of immune responses publication-title: Nat Rev Immunol doi: 10.1038/nri2567 contributor: fullname: Segura – ident: CR24 – volume: 71 start-page: 4055 year: 2014 end-page: 4067 ident: CR46 article-title: Critical role of extracellular vesicles in modulating the cellular effects of cytokines publication-title: Cell Mol Life Sci doi: 10.1007/s00018-014-1618-z contributor: fullname: Szabo – volume: 4 start-page: 501 year: 2013 end-page: 518 ident: CR18 article-title: Aggregation and fusion of low-density lipoproteins and publication-title: Biomol Concepts doi: 10.1515/bmc-2013-0016 contributor: fullname: Gursky – ident: CR20 – ident: BFsrep24316_CR42 doi: 10.3402/jev.v3.24858 – volume: 13 start-page: 43 year: 2015 ident: BFsrep24316_CR21 publication-title: Cell Rep doi: 10.1016/j.celrep.2015.08.057 contributor: fullname: G van Niel – volume: 13 start-page: 3354 year: 2013 ident: BFsrep24316_CR39 publication-title: Proteomics doi: 10.1002/pmic.201300282 contributor: fullname: H Kalra – volume: 9 start-page: 187 year: 1968 ident: BFsrep24316_CR22 publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)43118-9 contributor: fullname: MM Salpeter – volume: 10 start-page: 919 year: 2012 ident: BFsrep24316_CR27 publication-title: J Thromb Haemost doi: 10.1111/j.1538-7836.2012.04683.x contributor: fullname: E Van der Pol – volume: 52 start-page: 1695 year: 2014 ident: BFsrep24316_CR13 publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2013-0358 contributor: fullname: I Ramasamy – volume: 171 start-page: 3025 year: 2003 ident: BFsrep24316_CR43 publication-title: J Immunol doi: 10.4049/jimmunol.171.6.3025 contributor: fullname: EI Buzas – volume: 1 start-page: 583 year: 2007 ident: BFsrep24316_CR26 publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2007.10.001 contributor: fullname: WC Cromwell – volume: 290 start-page: C990 year: 2006 ident: BFsrep24316_CR38 publication-title: Am J Physiol-Cell Ph doi: 10.1152/ajpcell.00308.2005 contributor: fullname: SG Liu – ident: BFsrep24316_CR45 doi: 10.3402/jev.v3.24692 – ident: BFsrep24316_CR24 doi: 10.1371/journal.pone.0121184 – volume: 74 start-page: 2025 year: 2011 ident: BFsrep24316_CR44 publication-title: J Proteomics doi: 10.1016/j.jprot.2011.05.023 contributor: fullname: L Turiak – volume: 30 start-page: 255 year: 2014 ident: BFsrep24316_CR3 publication-title: Annu Rev Cell Dev Bi doi: 10.1146/annurev-cellbio-101512-122326 contributor: fullname: M Colombo – volume: 126 start-page: 5553 year: 2013 ident: BFsrep24316_CR4 publication-title: J Cell Sci doi: 10.1242/jcs.128868 contributor: fullname: M Colombo – ident: BFsrep24316_CR36 doi: 10.1095/biolreprod.113.113266 – volume: 74 start-page: 942 year: 2011 ident: BFsrep24316_CR48 publication-title: J Proteomics doi: 10.1016/j.jprot.2011.01.007 contributor: fullname: L Turiak – volume: 117 start-page: e39 year: 2011 ident: BFsrep24316_CR19 publication-title: Blood doi: 10.1182/blood-2010-09-307595 contributor: fullname: B Gyorgy – volume: 9 start-page: 581 year: 2009 ident: BFsrep24316_CR1 publication-title: Nat Rev Immunol doi: 10.1038/nri2567 contributor: fullname: C Thery – volume: 111 start-page: 518 year: 2014 ident: BFsrep24316_CR40 publication-title: Thromb Haemostasis doi: 10.1160/Th13-02-0178 contributor: fullname: M Dashty – volume: 64 start-page: 196 year: 2014 ident: BFsrep24316_CR15 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2014.05.015 contributor: fullname: PB Morris – ident: BFsrep24316_CR16 – volume: 15 start-page: 923 year: 2014 ident: BFsrep24316_CR35 publication-title: Chembiochem doi: 10.1002/cbic.201400043 contributor: fullname: N Kastelowitz – ident: BFsrep24316_CR10 – volume: 4 start-page: 501 year: 2013 ident: BFsrep24316_CR18 publication-title: Biomol Concepts doi: 10.1515/bmc-2013-0016 contributor: fullname: M Lu – volume: 16 start-page: 895 year: 2001 ident: BFsrep24316_CR34 publication-title: Biosens Bioelectron doi: 10.1016/S0956-5663(01)00235-4 contributor: fullname: G Siegel – volume: 216 start-page: 501 year: 1995 ident: BFsrep24316_CR17 publication-title: Biochem Bioph Res Co doi: 10.1006/bbrc.1995.2651 contributor: fullname: M Aviram – volume: 18 start-page: 883 year: 2012 ident: BFsrep24316_CR9 publication-title: Nat Med doi: 10.1038/nm.2753 contributor: fullname: H Peinado – volume: 13 start-page: 9775 year: 2015 ident: BFsrep24316_CR23 publication-title: Org Biomol Chem doi: 10.1039/c5ob01451d contributor: fullname: X Osteikoetxea – volume: 30 start-page: 1819 year: 1989 ident: BFsrep24316_CR28 publication-title: Journal of Lipid Research doi: 10.1016/S0022-2275(20)38212-2 contributor: fullname: LJ Anderson – volume: 106 start-page: 181 year: 2014 ident: BFsrep24316_CR33 publication-title: J Proteomics doi: 10.1016/j.jprot.2014.04.030 contributor: fullname: A von Zychlinski – volume: 68 start-page: 2667 year: 2011 ident: BFsrep24316_CR2 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-011-0689-3 contributor: fullname: B Gyorgy – ident: BFsrep24316_CR47 doi: 10.3402/jev.v3.23430 – volume: 10 start-page: 356 year: 2014 ident: BFsrep24316_CR8 publication-title: Nat Rev Rheumatol doi: 10.1038/nrrheum.2014.19 contributor: fullname: EI Buzas – ident: BFsrep24316_CR29 doi: 10.14814/phy2.12018 – ident: BFsrep24316_CR6 doi: 10.1371/journal.pone.0049726 – volume: 15 start-page: 15530 year: 2014 ident: BFsrep24316_CR37 publication-title: Int J Mol Sci doi: 10.3390/ijms150915530 contributor: fullname: J Liao – ident: BFsrep24316_CR5 – ident: BFsrep24316_CR32 doi: 10.1186/1476-511X-12-179 – volume: 133 start-page: 285 year: 2014 ident: BFsrep24316_CR11 publication-title: Thromb Res doi: 10.1016/j.thromres.2013.11.010 contributor: fullname: B Gyorgy – volume: 523 start-page: 177 year: 2015 ident: BFsrep24316_CR7 publication-title: Nature doi: 10.1038/nature14581 contributor: fullname: SA Melo – volume: 37 start-page: 579 year: 1980 ident: BFsrep24316_CR25 publication-title: Atherosclerosis doi: 10.1016/0021-9150(80)90065-9 contributor: fullname: EB Smith – ident: BFsrep24316_CR14 doi: 10.1016/S0167-7306(02)36020-4 – volume: 46 start-page: 1638 year: 2000 ident: BFsrep24316_CR31 publication-title: Clin Chem doi: 10.1093/clinchem/46.10.1638 contributor: fullname: AM Lorec – volume: 11 start-page: 1190 year: 2013 ident: BFsrep24316_CR41 publication-title: J Thromb Haemost doi: 10.1111/jth.12207 contributor: fullname: R Lacroix – ident: BFsrep24316_CR20 doi: 10.3402/jev.v3.23262 – volume: 36 start-page: 1155 year: 1995 ident: BFsrep24316_CR30 publication-title: Journal of Lipid Research doi: 10.1016/S0022-2275(20)41124-1 contributor: fullname: JS Millar – volume: 71 start-page: 4055 year: 2014 ident: BFsrep24316_CR46 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-014-1618-z contributor: fullname: GT Szabo – ident: BFsrep24316_CR12 doi: 10.3402/jev.v2i0.20360 |
| SSID | ssj0000529419 |
| Score | 2.6451087 |
| Snippet | Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and... Abstract Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their... |
| SourceID | pubmedcentral proquest crossref pubmed springer |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 24316 |
| SubjectTerms | 14/28 631/1647/1407/1492 631/1647/2230 82/16 82/58 Adult Biomarkers - blood Blood Blood platelets Blood Platelets - chemistry Body fluids Data interpretation Data processing Electron microscopy Exosomes Exosomes - chemistry Extracellular Vesicles - chemistry Female Flow cytometry Humanities and Social Sciences Humans Lipoproteins Lipoproteins, LDL - blood Low density lipoprotein Male multidisciplinary Postprandial Period Purification Science Transmission electron microscopy Vesicles |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1JT90wEB5REFIvFVvbAK1c4BrxnBfHzgkhVIQq2lOR3i3yFjVSs0DC9u8ZOws8kDjl4JFizefMfJkZzwAcMaMUkwz_VGWqwzhVNFSMq1DFEc9VbGXu4x2__yQXV_GvBVsMAbd2KKscbaI31KbWLkZ-TEUqEjHjKT9prkM3NcplV4cRGh9gjUazxJV08QWfYiwuixXTdGwoNBfH6HaayN3-XnZDb7jl2xLJV3lS737ON-DTwBvJaQ_0JqzYagvW-0mSj9tQXtb3oXHF6N0j-V80te-_UFSkLMpCt8TXp5MGqXIpUe4GbZwh9qFu69K2RFYGBXGnd7b1ZXKkv71ICjyZHjovYmznC7eqHbg6__n37CIcJimEms3iLkws8i6mDZMGfwFR_zY2-GBIJyKVM8YlwoUKzBU3UWoVS_TcSGm5VqkUWsw_w2pVV_YrkFxQzTWjNrcsjkwupYMTdZ0n6AyNCuBgVGzW9A0zMp_onots0n4A-6PKs-GbabNnhAP4MS3jaXcpDFnZ-hZlHKGhHI1KAF96hKa3RHzmkrY0AL6E3STgOmkvr1TFP99R20VUGYsCOBxRfrGt15vffX_ze_ARSVXiMk5U7MNqd3NrvyFx6dR3fzqfAPdR9NA priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwEB7xUCUuVUtbSLsg87imbLxx7ByqClWsEAJOXYlb5FdEJJJsN-Gx_75jZ7NigQMnHzxRRvM5ns-Z8QzAMTNKMcnwpCpTHcapikLFuApVTHmuYitz_7_j6jo5n8QXN-xmDfoemwsDNm8e7Vw_qcns7ufTv_lv_OB_dVfGxQn6kil1V7rXYRPHkevgcLVg-V2Jb5rGUdrXFXr-xKo3ekUxX2dKvgiXei80_gQfF_SRnHZ4f4Y1W23Dh66h5PwLlJf1Y2hcTno7J3fFtPZlGIqKlEVZ6Ib4NHUyRcZcSpSb4VZniH2qm7q0DZGVQUHU9ME2PluOdJcYSYEL1CPoRYxtff5W9RUm47O_f87DRUOFULNh3IaJRfrFtGHS4EkQYbCxwYEhq6AqZ4xLRI0Ok1xxQ1OrWKJHRkrLtUql0GL0DTaqurK7QHIRaa5ZZHPLYmpyKR2qaOs8QZ9oVACHvWGzaVc3I_Px7pHIltYPYNCbPOuRzyKRikQMecoDOFhO46J3kQxZ2foeZRyviTjuLQHsdAgt30L50MVuowD4CnZLAVdQe3WmKm59YW33Y5UxGsBRj_IztV4q__0d2v2ALSRYiYs-RWIAG-3s3u4hiWnVvl-i_wGXp_jH priority: 102 providerName: Scholars Portal – databaseName: Springer Open Access dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT4QwEJ7oGhMvxrfoaurjSlxYSsvRbDTGqCdNvJG-iCQCmwVf_95pWYirF08cOoRmvtL52m86BTinWkoqKK5URaL8KJGBLymTvoxClsnIiMztd9w_xDdP0e0zfV6Ck-4szIJ-P-YXGCemoT2uvQwrGHq5zdqaxJN-G8UKVVGQdDWDfr6xGGn-0Me_WZC_pFAXYa43YH1ODclli-UmLJlyC1bbyyK_tqG4qz58bfPNmy_ymk8rV2IhL0mRF7mqiUtBJ1Nkw4VAuxlOY5qYz6quClMTUWo0xJ6-m9plwpH2gCLJcfA5dJyJNo3LzSp34On66nFy488vS_AVHUWNHxukVlRpKjSu8tDFJtL4oMgYQplRygQiEo7iTDIdJkbSWI21EIYpmQiu-HgXBmVVmn0gGQ8UUzQwmaFRqDMhLGLo6yzGeKelB6edY9NpWxMjdVr2mKe99z0Ydi5P579FnQY84TEfsYR5cNI344C2KoUoTfWGNpazBAznDQ_2WoT6r4RsZHXZwAO2gF1vYItlL7aU-Ysrmm03TSkNPTjrUP7Rrd-dP_iX1SGsIX2KrbYU8CEMmtmbOUKK0shjN0i_AaCV6sI priority: 102 providerName: Springer Nature |
| Title | Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection |
| URI | https://link.springer.com/article/10.1038/srep24316 https://www.ncbi.nlm.nih.gov/pubmed/27087061 https://www.proquest.com/docview/1898680797 https://search.proquest.com/docview/1782217793 https://pubmed.ncbi.nlm.nih.gov/PMC4834552 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB6SlEIvpe-4TRf1cXV27ZUs-ZgsCaF0QygN7M3oZWqIZRM7bfLvM5LXSza59WJjNNhjfWPPJ81oBPCdGaWYZDhSlbmOaa6SWDGuYkVTXipqZRnmO5bn2dkl_bFiqx1g41qYkLSvVXXorupDV_0JuZVtradjntj0YrnwE2CMpdNd2EUDfTBEHwp6pzlN8rGK0FxM0de0qV_y7Sv_8pmP7CXbbugJt3yaIvkoThrcz-kreLnmjeRo0O817Fj3Bp4PO0nevYX6Z_MvNj4Zvb8jV1XbhPoLlSN1VVe6IyE_nbRIlWuJctf4jzPE3jZdU9uOSGdQEDX9a7vw-mRYvUgqtMwAXRAxtg-JW-4dXJ6e_F6cxeudFGLNZrSPM4u8i2nDpMEhIPa_pQZPDOlEqkrGuES40llWKm7S3CqW6bmR0nKtcim0mL-HPdc4uw-kFInmmiW2tIymppTSw4ndXmboDI2K4OvYsUU7FMwoQqB7LooNEBEcjF1erL-ZrkhELjIx4zmP4MumGa3dhzCks80NynhCk3D8qUTwYUBo85QR2gj4FnYbAV9Je7sFDSxU1F4bVATfRpQfqPVY-Y__ff9P8AL5VuaDUYk4gL3--sZ-Rk7Tqwla8opP4NnxyfnFL7xaZItJmB_A45KKSbDxe009AtQ |
| link.rule.ids | 230,315,730,783,787,867,888,12068,21400,24330,27936,27937,31731,31732,33756,33757,41132,42201,43322,43817,51588,53804,53806,74079,74636 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB61IFQuVR9A09LiPq4Rm2wcO6eqrUALLKsKgcQt8isiUvNgE1r494ydR7sg9ZRDRsrInzPzeWY8A_CFaimpoHhSFYnyo0QGvqRM-jIKWSYjIzIX7zhdxLOL6PiSXvYBt6YvqxxsojPUulI2Rr4f8ITHfMIS9rW-9u3UKJtd7UdoPIV126oKD1_r3w8WP8_GKIvNY0VBMrQUmvJ9dDx1aO9_rzqiR-zycZHkg0ypc0CHL-B5zxzJtw7ql_DElK9go5slefcainn1x9e2HL29I7_yunIdGPKSFHmRq4a4CnVSI1kuBMot0cppYm6rpipMQ0SpURA1_W0aVyhHuvuLJMe96cBzItq0rnSr3IKLw4PzHzO_n6XgKzqJWj82yLyo0lRoPAQiAibS-KBIKEKZUcoEAhZO4kwyHSZG0lhNtRCGKZkIrvh0G9bKqjRvgGQ8UEzRwGSGRqHOhLCA4lpnMbpDLT34NCxsWnctM1KX6p7ydFx9D3aHJU_7v6ZJ_2LswcfxNe53m8QQpaluUMZSmoChWfFgp0No_ErIJjZtG3jAVrAbBWwv7dU3ZX7lemrbmCqloQefB5T_Ueuh8m__r_wePJudn87T-dHi5B1sIsWKbf4p4Luw1i5vzHukMa380O_Ve769-SY |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9RADLagCMQFtQVKaCnD4xrtJpvJTE4Ila4KtBUHKu0tmqcaqXnQpED_fT2TB2wr9ZRDLMXy59ge22MDfKRaSioonlRFpsIkk1EoKZOhTGJmZWKE9fmOk9P06Cz5tqKrof-pHdoqR5voDbWulcuRzyKe8ZTPWcZmdmiL-PFl-an5FboNUq7SOqzTeAiPGJ5SnIazFZvyLa6ilUTZOFxowWfogprY3QRfd0l34sy77ZK3aqbeFS034dkQQ5LPPehb8MBU2_C43yp5_RzK4_pPqF1jendNLoqm9rMYioqURVmolvheddJg2FwKpLtEe6eJ-Vu3dWlaIiqNhMjpb9P6ljnS32QkBWqph9GTaNP5Jq7qBZwtD38eHIXDVoVQ0XnShanBGIwqTYXG4yBiYRKND4qhRSwtpUwgdPE8tZLpODOSpmqhhTBMyUxwxRcvYaOqK_MKiOWRYopGxhqaxNoK4aBFWdsUHaOWAbwfBZs3_fCM3Be9FzyfpB_A3ijyfPh_2vwf2gG8m16j5rtyhqhMfYU0LriJGBqYAHZ6hKavxGzuCrhRAGwNu4nATdVef1MV5366tsuuUhoH8GFE-T-2bjP_-n7m38ITVNL8-Ovp9114irFW6gpREd-Dje7yyrzBeKaT-15RbwDTMvv1 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Low-density+lipoprotein+mimics+blood+plasma-derived+exosomes+and+microvesicles+during+isolation+and+detection&rft.jtitle=Scientific+reports&rft.au=S%C3%B3dar%2C+Barbara+W&rft.au=Kittel%2C+%C3%81gnes&rft.au=P%C3%A1l%C3%B3czi%2C+Krisztina&rft.au=Vukman%2C+Krisztina+V&rft.date=2016-04-18&rft.eissn=2045-2322&rft.volume=6&rft.spage=24316&rft.epage=24316&rft_id=info:doi/10.1038%2Fsrep24316&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |