Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

• Published in: Scientific reports Vol. 6; no. 1; p. 19579
• Main Authors: Fan, Ching-Hsiang, Ting, Chien-Yu, Lin, Chung‐Yin, Chan, Hong-Lin, Chang, Yuan-Chih, Chen, You-Yin, Liu, Hao-Li, Yeh, Chih-Kuang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.01.2016; Nature Publishing Group
• Subjects: 639/301/54/152; 692/308/2056; 692/4017; Animal diseases; Animal models; Animals; Blood-brain barrier; Blood-Brain Barrier - metabolism; Cell Line; Central nervous system; Disease Models, Animal; Dopamine receptors; Gene Expression; Gene transfer; Gene Transfer Techniques; Genetic Therapy; Glial cell line-derived neurotrophic factor; Glial Cell Line-Derived Neurotrophic Factor - genetics; Glial Cell Line-Derived Neurotrophic Factor - metabolism; Humanities and Social Sciences; Injection; Microbubbles; Motor Activity; Movement disorders; multidisciplinary; Neurodegenerative diseases; Neuronal-glial interactions; Neuroprotection; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Permeability; Phenotype; Plasmids - administration & dosage; Plasmids - genetics; Plasmids - metabolism; Rats; Recovery of function; Science; Transfection; Ultrasonic imaging; Ultrasonic Waves; Ultrasound

Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons. CNS gene delivery currently relies on invasive intracerebral injection to transit the blood-brain barrier. Non-viral gene delivery via systematic transvascular route is an attractive alternat...