Direct observation of correlated interdomain motion in alcohol dehydrogenase
Interdomain motions in proteins are essential to enable or promote biochemical function. Neutron spin-echo spectroscopy is used to directly observe the domain dynamics of the protein alcohol dehydrogenase. The collective motion of domains as revealed by their coherent form factor relates to the clef...
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Published in | Physical review letters Vol. 101; no. 13; p. 138102 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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United States
26.09.2008
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Abstract | Interdomain motions in proteins are essential to enable or promote biochemical function. Neutron spin-echo spectroscopy is used to directly observe the domain dynamics of the protein alcohol dehydrogenase. The collective motion of domains as revealed by their coherent form factor relates to the cleft opening dynamics between the binding and the catalytic domains enabling binding and release of the functional important cofactor. The cleft opening mode hardens as a result of an overall stiffening of the domain complex due to the binding of the cofactor. |
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AbstractList | Interdomain motions in proteins are essential to enable or promote biochemical function. Neutron spin-echo spectroscopy is used to directly observe the domain dynamics of the protein alcohol dehydrogenase. The collective motion of domains as revealed by their coherent form factor relates to the cleft opening dynamics between the binding and the catalytic domains enabling binding and release of the functional important cofactor. The cleft opening mode hardens as a result of an overall stiffening of the domain complex due to the binding of the cofactor. |
Author | Biehl, Ralf Monkenbusch, Michael Falus, Peter Préost, Sylvain Richter, Dieter Hoffmann, Bernd Merkel, Rudolf |
Author_xml | – sequence: 1 givenname: Ralf surname: Biehl fullname: Biehl, Ralf organization: Institut für Festkörperforschung, Forschungszentrum Jülich, D-52425 Jülich, Germany – sequence: 2 givenname: Bernd surname: Hoffmann fullname: Hoffmann, Bernd – sequence: 3 givenname: Michael surname: Monkenbusch fullname: Monkenbusch, Michael – sequence: 4 givenname: Peter surname: Falus fullname: Falus, Peter – sequence: 5 givenname: Sylvain surname: Préost fullname: Préost, Sylvain – sequence: 6 givenname: Rudolf surname: Merkel fullname: Merkel, Rudolf – sequence: 7 givenname: Dieter surname: Richter fullname: Richter, Dieter |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18851497$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - metabolism Models, Chemical Models, Molecular NAD - chemistry NAD - metabolism Protein Structure, Tertiary Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Temperature Thermodynamics |
Title | Direct observation of correlated interdomain motion in alcohol dehydrogenase |
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