Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine

• Published in: Scientific reports Vol. 6; no. 1; p. 27634
• Main Authors: Ochi, Takanori, Feng, Yongjia, Kitamoto, Sho, Nagao-Kitamoto, Hiroko, Kuffa, Peter, Atarashi, Koji, Honda, Kenya, Teitelbaum, Daniel H., Kamada, Nobuhiko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.06.2016; Nature Publishing Group
• Subjects: 13/21; 631/250/2504/342; 631/250/347; 64/60; Amino acids; Amino Acids - metabolism; Animal Feed; Animals; Antigens, CD - metabolism; CD11b Antigen - metabolism; CD4-Positive T-Lymphocytes - cytology; Chemokine CCL2 - metabolism; Cytokines - metabolism; Dendritic cells; Gastrointestinal Microbiome; Homeostasis; Humanities and Social Sciences; Integrin alpha Chains - metabolism; Interleukin-10 - metabolism; Intestinal Mucosa - metabolism; Intestine, Small - metabolism; Intestine, Small - microbiology; Lymphocytes; Macrophages - metabolism; Macrophages - microbiology; Male; Mice; Mice, Inbred C57BL; Microbiota; Monocytes - metabolism; Mucous Membrane - metabolism; Mucous Membrane - microbiology; multidisciplinary; Nutrients; Nutrition; Parenteral nutrition; Receptors, CCR2 - metabolism; Regulation; Science; Small intestine; Ann Arbor Michigan; United States > US

Intestinal resident macrophages (Mϕs) regulate gastrointestinal homeostasis via production of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by circulating monocytes is required to maintain the pool of resident Mϕs in the colonic mucosa, the homeostatic regulati...