Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer

• Published in: Carcinogenesis (New York) Vol. 24; no. 2; pp. 275 - 282
• Main Authors: Barrett, J.H., Smith, G., Waxman, R., Gooderham, N., Lightfoot, T., Garner, R.C., Augustsson, K., Wolf, C.R., Bishop, D.T., Forman, D.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2003; Oxford Publishing Limited (England)
• Subjects: Aged; Aged, 80 and over; Amines - metabolism; Arylamine N-Acetyltransferase - metabolism; Base Sequence; Biological and medical sciences; Carcinogens - metabolism; Case-Control Studies; Colorectal Neoplasms - chemically induced; Colorectal Neoplasms - enzymology; DNA Primers; Female; FFQ; food frequency questionnaire; Gastroenterology. Liver. Pancreas. Abdomen; Genotype; heterocyclic amines; Humans; Male; Meat; Medical sciences; Middle Aged; N-acetyltransferase 2; NAT2; Phenotype; Risk Factors; single nucleotide polymorphisms; SNPs; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; United Kingdom; Europe; Bakery product; Rectal disease; Food habit; Tobacco smoking; Case control study; Epidemiology; Predisposition; Genetics; Intestinal disease; Colon; Beef; Heterocyclic compound; Human; Enzyme; Transferases; Genotype; Malignant tumor; Colonic disease; Carcinogen; Allele; Risk factor; Rectum; Digestive diseases; Aromatic amine; Polymorphism

Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA), which are produced by meat cooked at high temperatures and are found in cigarette smoke. A study of 500 incident colorectal cancer cases and po...