Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 5; pp. 1384 - 1394.e2
• Main Authors: Keles, Sevgi, Charbonnier, Louis Marie, Kabaleeswaran, Venkataraman, Reisli, Ismail, Genel, Ferah, Gulez, Nesrin, Al-Herz, Waleed, Ramesh, Narayanaswamy, Perez-Atayde, Antonio, Karaca, Neslihan E., Kutukculer, Necil, Wu, Hao, Geha, Raif S., Chatila, Talal A.
• Format: Journal Article
• Language: English
• Published: St. Louis Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: Bacterial infections; Cell division; Cell division cycle 42; Crystal structure; dedicator of cytokinesis 8; guanine nucleotide exchange factor; hyper-IgE syndrome; Infections; Liver; Microscopy; mucocutaneous candidiasis; Mutation; Patients; Phosphorylation; Proteins; signal transducer and activator of transcription 3; suppressor of cytokine signaling 3; TH17; suppressor of cytokine signaling 3; IL-6R; AD; DOCK8; GEF; signal transducer and activator of transcription 3; SOCS; ChIP; hyper-IgE syndrome; dedicator of cytokinesis 8; HIES; AR; Na3VO4; STAT; guanine nucleotide exchange factor; Cell division cycle 42; mucocutaneous candidiasis; pSTAT3; Rac1; TH17; GAPDH; WT; Cdc42; RORγt

The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES because of signal transducer and activator of transcription 3 (STAT3) mutations, including recurrent infections and mucocutaneous candidiasi...