AURANTIMYCINS, NEW DEPSIPEPTIDE ANTIBIOTICS FROM STREPTOMYCES-AURANTIACUS IMET-43917 PRODUCTION, ISOLATION, STRUCTURE ELUCIDATION, AND BIOLOGICAL-ACTIVITY
Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field home- a...
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| Published in | Journal of antibiotics Vol. 48; no. 2; pp. 119 - 125 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
TOKYO
JAPAN ANTIBIOT RES ASSN
1995
Japan Antibiotics Research Association |
| Subjects | |
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| Abstract | Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field home- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-999 mouse fibroblast cells. |
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| AbstractList | Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells. Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field home- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-999 mouse fibroblast cells. |
| Author | RITZAU, M HARTL, A IHN, W PAULUS, EF STENGEL, C GUTSCHE, W GRAFE, U DORNBERGER, K SCHLEGEL, R FLECK, WF |
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| Keywords | FERMENTATION AMINO-ACIDS Antibiotic Depsipeptide Toxicity Chemical structure Cytotoxicity Isolation Antibacterial agent In vitro Biological activity |
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| References | GRAFE U (WOS:A1995QK15900005.2) 1994; 3 KATAYAMA, N (WOS:A1993KJ51900009) 1993; 46 MAEHR, H (WOS:A1986AYK9200004) 1986; 39 HURLEY, TR (WOS:A1986F376300002) 1986; 39 SHELDRICK GM (WOS:A1995QK15900005.11) 1990 SZOKAN, G (WOS:A1988P414300012) 1988; 444 YAMAZAKI, S (WOS:A1986D793500001) 1986; 39 WESTLEY JW (WOS:A1995QK15900005.16) 1982; 1 GRAFE, U (WOS:A1994NQ23000011) 1994; 49 SMITKA, TA (WOS:A1988N917600003) 1988; 41 SHELDRICK GM (WOS:A1995QK15900005.10) 1993 SHIRLING E B (BCI:BCI197051044627) 1969; 19 NAKAGAWA, M (WOS:A1990DK69300005) 1990; 43 BRUCKNER, H (WOS:A1990EQ22100003) 1990; 30 GRIGOREV P (WOS:A1995QK15900005.4) 1994 HENSENS, OD (WOS:A1991FD87000018) 1991; 44 UHNO M (WOS:A1995QK15900005.15) 1993; 46 |
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| SubjectTerms | Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Biotechnology & Applied Microbiology Cell Line Cytotoxins - biosynthesis Cytotoxins - chemistry Cytotoxins - isolation & purification Cytotoxins - pharmacology Fibroblasts - cytology Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Immunology Life Sciences & Biomedicine Magnetic Resonance Spectroscopy Mice Microbiology Molecular Structure Peptides Pharmacology & Pharmacy Science & Technology Spectrometry, Mass, Fast Atom Bombardment Streptomyces - metabolism X-Ray Diffraction |
| Title | AURANTIMYCINS, NEW DEPSIPEPTIDE ANTIBIOTICS FROM STREPTOMYCES-AURANTIACUS IMET-43917 PRODUCTION, ISOLATION, STRUCTURE ELUCIDATION, AND BIOLOGICAL-ACTIVITY |
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