Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection

• Published in: Scientific reports Vol. 6; no. 1; p. 37242
• Main Authors: Huang, Weiwei, Wang, Shijie, Yao, Yufeng, Xia, Ye, Yang, Xu, Li, Kui, Sun, Pengyan, Liu, Cunbao, Sun, Wenjia, Bai, Hongmei, Chu, Xiaojie, Li, Yang, Ma, Yanbing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.11.2016; Nature Publishing Group
• Subjects: 13/21; 631/250/590/2294; 631/326/41/2537; 639/925/350/354; 64/60; 82/1; Animal models; Antibodies; Antigens; Bacterial infections; Bactericidal activity; Clinical isolates; Cytokines; Humanities and Social Sciences; Immune response; Immunization; Immunogenicity; Inflammation; Kidneys; Liver; Lungs; Membrane proteins; Membrane vesicles; multidisciplinary; Opsonophagocytosis; Outer membrane proteins; Rodents; Science; Sepsis; Serum levels; Spleen

Outer membrane vesicles (OMVs) have proven to be highly immunogenic and induced an immune response against bacterial infection in human clinics and animal models. We sought to investigate whether engineered OMVs can be a feasible antigen-delivery platform for efficiently inducing specific antibody r...