Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure

• Published in: Scientific reports Vol. 6; no. 1; p. 24907
• Main Authors: Suzuki, Jun, Corfas, Gabriel, Liberman, M. Charles
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.04.2016; Nature Publishing Group
• Subjects: 631/378/1686; 631/378/2619/1533; Administration, Topical; Animals; Brain stem; Cochlea; Confocal microscopy; Correction of Hearing Impairment - methods; Disease Models, Animal; Hearing loss; Hearing Loss, Sensorineural - therapy; Hearing protection; Humanities and Social Sciences; Mice; multidisciplinary; Neurotrophic factors; Neurotrophin 3; Neurotrophin 3 - administration & dosage; Recovery of function; Regeneration; Science; Sensory neurons; Synapses; Treatment Outcome

In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves. Because the cell bodies and central projections of these co...