DHEA in Elderly Women and DHEA or Testosterone in Elderly Men

• Published in: The New England journal of medicine Vol. 355; no. 16; pp. 1647 - 1659
• Main Authors: Nair, K. Sreekumaran, Rizza, Robert A, O'Brien, Peter, Dhatariya, Ketan, Short, Kevin R, Nehra, Ajay, Vittone, Janet L, Klee, George G, Basu, Ananda, Basu, Rita, Cobelli, Claudio, Toffolo, Gianna, Man, Chiara Dalla, Tindall, Donald J, Melton, L. Joseph, Smith, Glenn E, Khosla, Sundeep, Jensen, Michael D
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 19.10.2006
• Subjects: Adult; Aged; Aging; Aging - drug effects; Androgens; Biological and medical sciences; Body Composition - drug effects; Bone density; Bone Density - drug effects; Dehydroepiandrosterone - administration & dosage; Dehydroepiandrosterone - adverse effects; Dehydroepiandrosterone - blood; Double-Blind Method; Estradiol - blood; Female; General aspects; Hormone Replacement Therapy - adverse effects; Humans; Insulin Resistance; Male; Medical sciences; Middle Aged; Older people; Physical Fitness; Quality of Life; Testosterone - administration & dosage; Testosterone - adverse effects; Testosterone - blood; Treatment Failure; Women; Human; Medicine; Testosterone; Dehydroepiandrosterone; Androgen; Adult; Female; Male; Sex steroid hormone; Elderly

This 2-year controlled, randomized, double-blind study examined the effects of dehydroepiandrosterone (DHEA) in women and DHEA or testosterone in men, as compared with placebo. Neither DHEA nor low-dose testosterone replacement in the elderly subjects had physiologically relevant beneficial effects...