Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

• Published in: Scientific reports Vol. 5; no. 1; p. 14405
• Main Authors: Zhang, Xu, Zhao, Yufeng, Xu, Jia, Xue, Zhengsheng, Zhang, Menghui, Pang, Xiaoyan, Zhang, Xiaojun, Zhao, Liping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.09.2015; Nature Publishing Group
• Subjects: 631/158/855; 631/326/107; 631/326/2522; 631/326/2565/2134; Animals; Anti-Obesity Agents - pharmacology; Antidiabetics; Bacteria - classification; Bacteria - drug effects; Bacteria - metabolism; Base Sequence; Berberine; Berberine - pharmacology; Diabetes; Diabetes mellitus; Diet, High-Fat; Fatty acids; Fatty Acids, Volatile - biosynthesis; Feces - microbiology; Gastrointestinal Microbiome - drug effects; Gastrointestinal Tract - microbiology; High fat diet; Humanities and Social Sciences; Intestinal microflora; Male; Metabolic disorders; Metformin; Metformin - pharmacology; multidisciplinary; Obesity; Obesity - drug therapy; Rats; Rats, Wistar; Rodents; Science; Sequence Analysis, DNA

Accumulating evidence suggests that the gut microbiota is an important factor in mediating the development of obesity-related metabolic disorders, including type 2 diabetes. Metformin and berberine, two clinically effective drugs for treating diabetes, have recently been shown to exert their actions...