Fascin Expression in Diffuse Large B-Cell Lymphoma, Anaplastic Large Cell Lymphoma, and Classical Hodgkin Lymphoma

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 131; no. 5; pp. 742 - 747
• Main Authors: Bakshi, Nasir A., Finn, William G., Schnitzer, Bertram, Valdez, Riccardo, Ross, Charles W.
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.05.2007
• Subjects: Actin; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Care and treatment; Carrier Proteins - biosynthesis; Diagnosis; Diagnosis, Differential; Female; Health aspects; Hodgkin Disease - metabolism; Hodgkin Disease - pathology; Humans; Immunohistochemistry; Lymphoma, B-Cell - metabolism; Lymphoma, B-Cell - pathology; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Microfilament Proteins - biosynthesis; Middle Aged; Non-Hodgkin's lymphomas; Predictive Value of Tests; Sensitivity and Specificity; United States

Context.—Fascin is an actin-bundling protein involved in the formation of dendritic processes. Fascin is a sensitive marker for classical Reed-Sternberg cells and has a high negative predictive value for diagnosis of classical Hodgkin lymphoma (CHL). Fascin has been used to distinguish CHL from non-...