Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 126; no. 2; p. 499
• Main Authors: Aparicio, Thomas, Guilmeau, Sandra, Goiot, Hélène, Tsocas, Annick, Laigneau, Jean-Pierre, Bado, André, Sobhani, Iradj, Lehy, Thérèse
• Format: Journal Article
• Language: English
• Published: United States 01.02.2004
• Subjects: Animals; Azoxymethane; Carcinogens; Cell Division - drug effects; Colonic Neoplasms - chemically induced; Colonic Neoplasms - pathology; Colonic Neoplasms - prevention & control; Infusion Pumps; Injections; Intestinal Mucosa - drug effects; Intestinal Mucosa - pathology; Leptin - administration & dosage; Leptin - pharmacology; Male; Precancerous Conditions - chemically induced; Precancerous Conditions - pathology; Precancerous Conditions - prevention & control; Rats; Rats, Inbred F344; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacology

Recent studies suggest that leptin, a hormone involved in food intake regulation, released into the circulation and gastrointestinal juice, may be a growth factor for intestine and may be involved in carcinogenesis; however, data are contradictory. This study investigates in rat colonic mucosa (1) t...