Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy - Lin, Chin-Chih; Cheng, Tsung-Lin; Tsai, Wen-Hui; Tsai, Hui-Ju; Hu, Keng-Hsun; Chang, Hao-Chun; Yeh, Chin-Wei; Chen, Ying-Chou; Liao, Ching-Chun; Chang, Wen-Tsan (Scientific reports, 2012)
Keywords: 631/208/191/505; 631/45/320; 631/67/70; 631/80/641/83; Adenosine Triphosphate - pharmacology; Animals; Apoptosis Regulatory Proteins; Carrier Proteins - metabolism; Cell Line, Tumor; Cervical cancer; Citrate (si)-Synthase - antagonists & inhibitors; Citrate (si)-Synthase - genetics; Citrate (si)-Synthase - metabolism; Deregulation; Disease Progression; Energy Metabolism - drug effects; Enzymes; Epithelial-Mesenchymal Transition - drug effects; Female; HeLa Cells; Humanities and Social Sciences; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Leupeptins - pharmacology; Metabolism; Mice; Mice, Inbred NOD; Mitochondrial Proteins - metabolism; multidisciplinary; p53 Protein; Phenotype; Physical characteristics; Proteasome Endopeptidase Complex - chemistry; Proteasome Endopeptidase Complex - metabolism; Proteasomes; Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors; Proto-Oncogene Proteins c-mdm2 - genetics; Proto-Oncogene Proteins c-mdm2 - metabolism; RNA Interference; RNA, Small Interfering - metabolism; Science; Signal transduction; Signal Transduction - drug effects; Transplantation, Heterologous; Tumor Suppressor Protein p53 - metabolism; Tumors; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Xenografts