Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline

• Published in: Journal of Alzheimer's disease Vol. 62; no. 2; p. 745
• Main Authors: Del-Aguila, Jorge L, Fernández, Maria Victoria, Schindler, Suzanne, Ibanez, Laura, Deming, Yuetiva, Ma, Shengmei, Saef, Ben, Black, Kathleen, Budde, John, Norton, Joanne, Chasse, Rachel, Harari, Oscar, Goate, Alison, Xiong, Chengjie, Morris, John C, Cruchaga, Carlos
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - psychology; Dementia - genetics; Disease Progression; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Heterozygote; Humans; Longitudinal Studies; Male; Membrane Glycoproteins - genetics; Memory Disorders - genetics; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Immunologic - genetics; Risk Assessment; Clinical Dementia Rating sum of boxes; progression; International Genomics of Alzheimer’s Project (IGAP); polygenic risk score; Alzheimer’s disease risk

Many genetic studies for Alzheimer's disease (AD) have been focused on the identification of common genetic variants associated with AD risk and not on other aspects of the disease, such as age at onset or rate of dementia progression. There are multiple approaches to untangling the genetic arc...