Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense

• Published in: Scientific reports Vol. 7; no. 1; p. 43305
• Main Authors: He, Xiaolong, Zeng, Qing, Puthiyakunnon, Santhosh, Zeng, Zhijie, Yang, Weijun, Qiu, Jiawen, Du, Lei, Boddu, Swapna, Wu, Tongwei, Cai, Danxian, Huang, Sheng-He, Cao, Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.03.2017; Nature Publishing Group
• Subjects: 13/1; 13/106; 631/250/255/1318; 631/326/421; 692/420/254; Animal models; Cell culture; Colonization; Colorectal cancer; E coli; Escherichia coli; Gastrointestinal tract; Humanities and Social Sciences; Immunoglobulin A; Infections; Intestine; Mucin; multidisciplinary; Neonates; Permeability; Rodents; Science; Translocation; Zonula occludens-1 protein

The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. coli ) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neon...