Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense
The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. coli ) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neon...
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| Published in | Scientific reports Vol. 7; no. 1; p. 43305 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
06.03.2017
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The objective of this study was to determine whether
Lactobacillus rhamnosus
GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal
Escherichia coli (E. coli
) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neonatal rat models. Our
in vitro
results showed that LCS could block adhesion, invasion and translocation of
E. coli
K1 to Caco-2 monolayer via up-regulating mucin production and maintaining intestinal integrity.
In vivo
experiments revealed that pre-treatment with LCS significantly decrease susceptibility of neonatal rats to oral
E. coli
K1 infection as reflected by reduced bacterial intestinal colonization, translocation, dissemination and systemic infections. Further, we found that LCS treated neonatal rats have higher intestinal expressions of Ki67, MUC2, ZO-1, IgA, mucin and lower barrier permeability than those in untreated rats. These results indicated that LCS could enhance neonatal resistance to systemic
E. coli
K1 infection via promoting maturation of neonatal intestinal defense. In conclusions, our findings suggested that LCS has a prophylactic effect against systemic
E. coli
K1 infection in neonates. Future studies aimed at identifying the specific active ingredients in LCS will be helpful in developing effective pharmacological strategies for preventing neonatal
E. coli
K1 infection. |
|---|---|
| AbstractList | The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. coli) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neonatal rat models. Our in vitro results showed that LCS could block adhesion, invasion and translocation of E. coli K1 to Caco-2 monolayer via up-regulating mucin production and maintaining intestinal integrity. In vivo experiments revealed that pre-treatment with LCS significantly decrease susceptibility of neonatal rats to oral E. coli K1 infection as reflected by reduced bacterial intestinal colonization, translocation, dissemination and systemic infections. Further, we found that LCS treated neonatal rats have higher intestinal expressions of Ki67, MUC2, ZO-1, IgA, mucin and lower barrier permeability than those in untreated rats. These results indicated that LCS could enhance neonatal resistance to systemic E. coli K1 infection via promoting maturation of neonatal intestinal defense. In conclusions, our findings suggested that LCS has a prophylactic effect against systemic E. coli K1 infection in neonates. Future studies aimed at identifying the specific active ingredients in LCS will be helpful in developing effective pharmacological strategies for preventing neonatal E. coli K1 infection. The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic neonatal Escherichia coli (E. coli ) K1 infection. The preventive effects were evaluated in human colonic carcinoma cell line Caco-2 and neonatal rat models. Our in vitro results showed that LCS could block adhesion, invasion and translocation of E. coli K1 to Caco-2 monolayer via up-regulating mucin production and maintaining intestinal integrity. In vivo experiments revealed that pre-treatment with LCS significantly decrease susceptibility of neonatal rats to oral E. coli K1 infection as reflected by reduced bacterial intestinal colonization, translocation, dissemination and systemic infections. Further, we found that LCS treated neonatal rats have higher intestinal expressions of Ki67, MUC2, ZO-1, IgA, mucin and lower barrier permeability than those in untreated rats. These results indicated that LCS could enhance neonatal resistance to systemic E. coli K1 infection via promoting maturation of neonatal intestinal defense. In conclusions, our findings suggested that LCS has a prophylactic effect against systemic E. coli K1 infection in neonates. Future studies aimed at identifying the specific active ingredients in LCS will be helpful in developing effective pharmacological strategies for preventing neonatal E. coli K1 infection. |
| ArticleNumber | 43305 |
| Author | Du, Lei Boddu, Swapna Puthiyakunnon, Santhosh Cai, Danxian Zeng, Zhijie Wu, Tongwei He, Xiaolong Qiu, Jiawen Zeng, Qing Cao, Hong Huang, Sheng-He Yang, Weijun |
| Author_xml | – sequence: 1 givenname: Xiaolong surname: He fullname: He, Xiaolong organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 2 givenname: Qing surname: Zeng fullname: Zeng, Qing organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 3 givenname: Santhosh surname: Puthiyakunnon fullname: Puthiyakunnon, Santhosh organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 4 givenname: Zhijie surname: Zeng fullname: Zeng, Zhijie organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 5 givenname: Weijun surname: Yang fullname: Yang, Weijun organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 6 givenname: Jiawen surname: Qiu fullname: Qiu, Jiawen organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 7 givenname: Lei surname: Du fullname: Du, Lei organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 8 givenname: Swapna surname: Boddu fullname: Boddu, Swapna organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University – sequence: 9 givenname: Tongwei surname: Wu fullname: Wu, Tongwei organization: The First School of Clinical Medicine, Southern Medical University – sequence: 10 givenname: Danxian surname: Cai fullname: Cai, Danxian organization: The First School of Clinical Medicine, Southern Medical University – sequence: 11 givenname: Sheng-He surname: Huang fullname: Huang, Sheng-He organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Saban Research Institute, Children’s Hospital Los Angeles, University of Southern California – sequence: 12 givenname: Hong surname: Cao fullname: Cao, Hong email: gzhcao@smu.edu.cn organization: Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28262688$$D View this record in MEDLINE/PubMed |
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| Snippet | The objective of this study was to determine whether
Lactobacillus rhamnosus
GG culture supernatant (LCS) has a preventive effect against gut-derived systemic... The objective of this study was to determine whether Lactobacillus rhamnosus GG culture supernatant (LCS) has a preventive effect against gut-derived systemic... |
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| SubjectTerms | 13/1 13/106 631/250/255/1318 631/326/421 692/420/254 Animal models Cell culture Colonization Colorectal cancer E coli Escherichia coli Gastrointestinal tract Humanities and Social Sciences Immunoglobulin A Infections Intestine Mucin multidisciplinary Neonates Permeability Rodents Science Translocation Zonula occludens-1 protein |
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| Title | Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense |
| URI | https://link.springer.com/article/10.1038/srep43305 https://www.ncbi.nlm.nih.gov/pubmed/28262688 https://www.proquest.com/docview/1903363918 https://www.proquest.com/docview/1874786524 https://pubmed.ncbi.nlm.nih.gov/PMC5338013 |
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