Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 125; no. 3; p. 805
• Main Authors: Tuo, Bi-Guang, Isenberg, Jon I
• Format: Journal Article
• Language: English
• Published: United States 01.09.2003
• Subjects: Acetylcholine - metabolism; Animals; Atropine - pharmacology; Bicarbonates - metabolism; Chlorides - metabolism; Dose-Response Relationship, Drug; Duodenum - drug effects; Duodenum - metabolism; Intestinal Mucosa - metabolism; Mice; NG-Nitroarginine Methyl Ester - pharmacology; Phentolamine - pharmacology; Propranolol - pharmacology; Serotonin - pharmacology; Tetrodotoxin - pharmacology

5-hydroxytryptamine (5-HT) is an important neurotransmitter and intercellular messenger that modulates many gastrointestinal functions. Because little is known about the role of 5-HT in the regulation of duodenal bicarbonate secretion, we examined the role of 5-HT on duodenal bicarbonate secretion a...