Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus

• Published in: The New England journal of medicine Vol. 322; no. 26; pp. 1836 - 1841
• Main Authors: Baisch, Jeanine M, Weeks, Tracy, Giles, Robert, Hoover, Marie, Stastny, Peter, Capra, J. Donald
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 28.06.1990
• Subjects: Acids; Adult; Alleles; Antigens; Aspartic acid; Base Sequence; Biological and medical sciences; Deoxyribonucleic acid; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - genetics; Diabetes. Impaired glucose tolerance; Disease Susceptibility; DNA; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Genotype; Genotypes; Haplotypes; Histocompatibility antigen HLA; HLA-DQ Antigens - analysis; HLA-DQ beta-Chains; Humans; Immunology; Insulin; Male; Medical research; Medical sciences; Molecular Sequence Data; Nucleotide Mapping; Oligonucleotides; Patients; Polymerase Chain Reaction; Proteins; Studies; Tissue typing; Human; Insulin dependent diabetes; HLA-System; Exploration; Hemopathy
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199006283222602

There is evidence that certain alleles at the HLA-DQ locus are correlated with susceptibility to insulin-dependent diabetes mellitus (IDDM) and in particular that DQ beta-chain alleles containing aspartic acid at position 57 are protective. The availability of a large group of patients with IDDM ena...