Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness

• Published in: Translational psychiatry Vol. 4; no. 3; p. e366
• Main Authors: Kohen, R, Dobra, A, Tracy, J H, Haugen, E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.03.2014; Nature Publishing Group
• Subjects: 631/208/212/2019; 631/378/1595/1554; 631/80/86; 692/699/476; Adult; Aged; Aged, 80 and over; Behavioral Sciences; Biological Psychology; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Dentate Gyrus - cytology; Dentate Gyrus - metabolism; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Female; Gene Expression Profiling - methods; Gene Expression Profiling - standards; Genotype; Humans; Laser Capture Microdissection - methods; Male; Medicine; Medicine & Public Health; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Neurosciences; Original; original-article; Pharmacotherapy; Psychiatry; Schizophrenia - genetics; Schizophrenia - metabolism; Tissue Banks; Transcriptome - genetics; microRNA; bipolar disorder; schizophrenia; RNA-seq; laser capture microdissection; major depression

This study is, to the best of our knowledge, the first application of whole transcriptome sequencing (RNA-seq) to cells isolated from postmortem human brain by laser capture microdissection. We investigated the transcriptome of dentate gyrus (DG) granule cells in postmortem human hippocampus in 79 s...