Neuroprotective effect of Betalain against AlCl3-induced Alzheimer's disease in Sprague Dawley Rats via putative modulation of oxidative stress and nuclear factor kappa B (NF-κB) signaling pathway

• Published in: Biomedicine & pharmacotherapy Vol. 137; p. 111369
• Main Authors: Shunan, Di, Yu, Miao, Guan, Huibo, Zhou, Yanyan
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.05.2021
• Subjects: Aluminium chloride (AlCl3); Alzheimer's disease (AD); Betalain; Dementia; Inflammation; Oxidative stress; Oxidative stress; Alzheimer's disease (AD); Aluminium chloride (AlCl3); Inflammation; Betalain; Dementia

Alzheimer's disease (AD) is the most progressive form of neurodegenerative disease, which severely impairs cognitive function. Oxidative stress is identified to contribute to the mechanisms responsible for the pathogenesis of such neurodegenerative diseases. Aluminum is a potent neurotoxin for...