Synchronous selection of homing peptides for multiple tissues by in vivo phage display

• Published in: The FASEB journal Vol. 20; no. 7; p. 979
• Main Authors: Kolonin, Mikhail G, Sun, Jessica, Do, Kim-Anh, Vidal, Claudia I, Ji, Yuan, Baggerly, Keith A, Pasqualini, Renata, Arap, Wadih
• Format: Journal Article
• Language: English
• Published: United States 01.05.2006
• Subjects: Amino Acid Motifs; Amino Acid Sequence; Animals; Brain - metabolism; Female; Intestinal Mucosa - metabolism; Kidney - metabolism; Ligands; Mice; Mice, Inbred C57BL; Muscle, Skeletal - metabolism; Organ Specificity; Pancreas - metabolism; Peptide Library; Peptides - chemistry; Peptides - metabolism; Receptors, Prolactin - metabolism; Reproducibility of Results; Uterus - metabolism

In vivo phage display is a technology used to reveal organ-specific vascular ligand-receptor systems in animal models and, recently, in patients, and to validate them as potential therapy targets. Here, we devised an efficient approach to simultaneously screen phage display libraries for peptides ho...