The PROTAC technology in drug development

• Published in: Cell biochemistry and function Vol. 37; no. 1; pp. 21 - 30
• Main Authors: Zou, Yutian, Ma, Danhui, Wang, Yinyin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2019; John Wiley and Sons Inc
• Subjects: Biodegradation; cancer; Drug development; Drug Development - methods; Humans; New technology; PROTAC; Proteasome Endopeptidase Complex - metabolism; protein degradation; Proteins; Proteolysis; Recombinant Fusion Proteins - metabolism; Review; small molecule; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; drug development; small molecule; cancer; PROTAC; protein degradation

Currently, a new technology termed PROTAC, proteolysis targeting chimera, has been developed for inducing the protein degradation by a targeting molecule. This technology takes advantage of a moiety of targeted protein and a moiety of recognizing E3 ubiquitin ligase and produces a hybrid molecule to...