Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans
Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were...
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| Published in | Journal of clinical pharmacology Vol. 32; no. 2; p. 136 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.02.1992
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were collected up to 24 hours after the dose and assayed for active and total HMG-CoA reductase inhibitors. After equal oral doses, higher plasma concentrations of HMG-CoA reductase inhibitory activity after pravastatin than after either lovastatin of simvastatin (2-3 fold greater area under the concentration-time curve) suggest a greater potential availability of pravastatin-related inhibitory activity to peripheral tissues. |
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| AbstractList | Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were collected up to 24 hours after the dose and assayed for active and total HMG-CoA reductase inhibitors. After equal oral doses, higher plasma concentrations of HMG-CoA reductase inhibitory activity after pravastatin than after either lovastatin of simvastatin (2-3 fold greater area under the concentration-time curve) suggest a greater potential availability of pravastatin-related inhibitory activity to peripheral tissues. |
| Author | Brunner-Ferber, F Schwartz, J I Pentikainen, P J Rogers, J D Saraheimo, M Schwartz, M S Amin, R D |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/1613123$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Administration, Oral Adult Drug Administration Schedule Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lovastatin - analogs & derivatives Lovastatin - pharmacokinetics Male Pravastatin - pharmacokinetics Simvastatin |
| Title | Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans |
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