Flexible longitudinal linear mixed models for multiple censored responses data

• Published in: Statistics in medicine Vol. 38; no. 6; pp. 1074 - 1102
• Main Authors: Lachos, Victor H., A. Matos, Larissa, Castro, Luis M., Chen, Ming‐Hui
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 15.03.2019
• Subjects: Algorithms; censored data; Economic models; HIV Infections - virology; HIV viral load; Humans; Likelihood Functions; Limit of Detection; Linear Models; Longitudinal Studies; multiple longitudinal responses; Multivariate Analysis; outliers; Polymerase Chain Reaction; SAEM algorithm; Time Factors; Viral Load - statistics & numerical data; SAEM algorithm; censored data; outliers; multiple longitudinal responses; HIV viral load

In biomedical studies and clinical trials, repeated measures are often subject to some upper and/or lower limits of detection. Hence, the responses are either left or right censored. A complication arises when more than one series of responses is repeatedly collected on each subject at irregular int...