Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy Adults - Landry, Ishani; Nakai, Kenya; Ferry, Jim; Aluri, Jagadeesh; Hall, Nancy; Lalovic, Bojan; Moline, Margaret L. (Clinical pharmacology in drug development, 2021)
Keywords: Adult; Age Factors; Aged; Asians; Dose-Response Relationship, Drug; Double-Blind Method; Female; Half-Life; Humans; Insomnia; lemborexant; Male; Middle Aged; orexin receptor antagonists; Orexin Receptor Antagonists - administration & dosage; Orexin Receptor Antagonists - adverse effects; Orexin Receptor Antagonists - pharmacokinetics; Original Manuscript; Pharmacodynamics; Pharmacokinetics; Pyridines - administration & dosage; Pyridines - adverse effects; Pyridines - pharmacokinetics; Pyrimidines - administration & dosage; Pyrimidines - adverse effects; Pyrimidines - pharmacokinetics; safety; Sex Factors; Whites; pharmacokinetics; orexin receptor antagonists; lemborexant; pharmacodynamics; safety; insomnia