Physical activity offsets genetic risk for incident depression assessed via electronic health records in a biobank cohort study

• Published in: Depression and anxiety Vol. 37; no. 2; pp. 106 - 114
• Main Authors: Choi, Karmel W., Zheutlin, Amanda B., Karlson, Rebecca A., Wang, Min‐Jung, Dunn, Erin C., Stein, Murray B., Karlson, Elizabeth W., Smoller, Jordan W.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2020
• Subjects: Biobanks; Cohort analysis; Cohort Studies; Databases, Genetic; depression; Depression - genetics; Depressive Disorder, Major - genetics; EHR; Electronic Health Records; Electronic medical records; Exercise; Exercise - physiology; Female; Genetics; Genome-Wide Association Study; Genomes; genomics; Health risk assessment; Humans; Male; Mental depression; Middle Aged; Multifactorial Inheritance - genetics; Physical activity; polygenic risk; prevention; resilience; Risk Factors; polygenic risk; exercise; genomics; depression; resilience; EHR; prevention

Background Physical activity is increasingly recognized as an important modifiable factor for depression. However, the extent to which individuals with stable risk factors for depression, such as high genetic vulnerability, can benefit from the protective effects of physical activity, remains unknow...