D prostanoid receptor 2 (chemoattractant receptor–homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells

• Published in: Journal of allergy and clinical immunology Vol. 135; no. 2; pp. 395 - 406.e7
• Main Authors: Stinson, Sally E., Amrani, Yassine, Brightling, Christopher E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2015; Elsevier Limited; Mosby
• Subjects: Adult; Airway Remodeling - genetics; Allergy and Immunology; Asthma; Asthma - diagnosis; Asthma - genetics; Asthma - immunology; Asthma - metabolism; Asthma and Lower Airway Disease; Biopsy; Bronchi - immunology; Bronchi - metabolism; Bronchi - pathology; Calcium - metabolism; Case-Control Studies; Cell Differentiation - genetics; Cell Movement; Cells, Cultured; Chronic obstructive pulmonary disease; Disease; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Epithelial Cells - cytology; Epithelial Cells - metabolism; Expression; Female; Humans; Immunohistochemistry; Male; Middle Aged; Pathogenesis; prostaglandin D2; Protein expression; Proteins; Respiratory Function Tests; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Risk Factors; Severity of Illness Index; Studies; Transcription Factors - genetics; Transcription Factors - metabolism; United Kingdom > UK; PGD2; DP1; Expression; prostaglandin D2; DP2; biopsy; CRTH2; DK-PGD2; asthma; immunohistochemistry; ALI; COPD; D prostanoid receptor 2; D prostanoid receptor 1; Air-liquid interface; DK-PGD 2; Chemoattractant receptor–homologous molecule expressed on T H2 cells; 13, 14-Dihydro-15-keto prostaglandin D 2; PGD 2; Chronic obstructive pulmonary disease; prostaglandin D 2; prostaglandin D

The D prostanoid receptor 2 (DP2; also known as chemoattractant receptor–homologous molecule expressed on TH2 cells) is implicated in the pathogenesis of asthma, but its expression within bronchial biopsy specimens is unknown. We sought to investigate the bronchial submucosal DP2 expression in asthm...