Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4⁺ T cells

• Published in: Clinical and experimental immunology Vol. 160; no. 2; pp. 223 - 232
• Main Authors: Wang, L.-C, Chu, K.-H, Liang, Y.-C, Lin, Y.-L, Chiang, B.-L
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.05.2010; Blackwell Publishing Ltd; Blackwell; Blackwell Science Inc
• Subjects: Akt; Analytical, structural and metabolic biochemistry; Biological and medical sciences; caffeic acid phenethyl ester; caspase-3; CD4+ T cells; CD4⁺ T cells; Fundamental and applied biological sciences. Psychology; NF-κB; Translational Studies; Human; CD4 T lymphocyte; Enzyme; Cysteine endopeptidases; Akt protein kinase; Biochemistry; Akt; T cells; Caffeic acid; Peptidases; Ester; NF-κB; CD4; Signaling pathway; Primary; caffeic acid phenethyl ester; Hydrolases; Inhibitor; Transcription factor NFκB; caspase-3

Caffeic acid phenethyl ester (CAPE), an active component in propolis, is known to have anti-tumour, anti-inflammatory and anti-oxidant properties. In this study, the effects of CAPE on the functions of primary human CD4⁺ T cells were evaluated in vitro. CAPE significantly suppressed interferon (IFN)...