The molecular pathophysiology of depression and the new therapeutics

• Published in: MedComm (2020) Vol. 3; no. 3; pp. e156 - n/a
• Main Authors: Tian, Haihua, Hu, Zhenyu, Xu, Jia, Wang, Chuang
• Format: Journal Article
• Language: English
• Published: China John Wiley & Sons, Inc 01.09.2022; John Wiley and Sons Inc; Wiley
• Subjects: (R)‐ketamine; (S)‐ketamine; Antidepressants; Drug therapy; Ketamine; major depressive disorder (MDD); Mental depression; Pathophysiology; Review; Reviews; ketamine; (S)‐ketamine; major depressive disorder (MDD); (R)‐ketamine

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the many hypotheses proposed to understand the molecular pathophysiology of depression, it is still unclear. Current treatments for depression are inadequate for many individuals, because of limited effectiveness,...