Epithelial cells and airway diseases

The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory...

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Bibliographic Details
Published inImmunological reviews Vol. 242; no. 1; pp. 186 - 204
Main Authors Proud, David, Leigh, Richard
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.07.2011
Subjects
airway remodeling
Airway Remodeling - immunology
Allergens
Allergens - immunology
Animals
Asthma
Asthma - drug therapy
Asthma - immunology
Asthma - physiopathology
Bronchodilator Agents - therapeutic use
Cell Adhesion Molecules - immunology
Child
Cytokines - immunology
Drugs
Environmental factors
epithelial cell
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - immunology
Epithelial Cells - metabolism
Epithelium
Epithelium - drug effects
Epithelium - immunology
Epithelium - metabolism
host defense
Humans
Hypersensitivity - drug therapy
Hypersensitivity - immunology
Hypersensitivity - physiopathology
Immune response
Immunity, Innate
Immunoregulation
inflammation
Inflammation - immunology
innate immunity
Intercellular Signaling Peptides and Proteins - immunology
Mice
Mice, Knockout
Pathogens
Picornaviridae Infections - immunology
Picornaviridae Infections - virology
Pollutants
Respiratory System - drug effects
Respiratory System - immunology
Respiratory System - physiopathology
Respiratory tract diseases
Respiratory Tract Infections - immunology
Respiratory Tract Infections - virology
Reviews
Rhinovirus - immunology
Rhinovirus - physiology
Signal Transduction - immunology
Structure-function relationships
Online AccessGet full text
ISSN0105-2896
1600-065X
1600-065X
DOI10.1111/j.1600-065X.2011.01033.x

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Abstract The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory status, structure, and function in normal and diseased airways. This article reviews our current knowledge regarding the roles of the epithelial cell in airway inflammation and host defense. The interactions of inhaled environmental factors and pathogens with epithelial cells are also discussed, with an emphasis on epithelial innate immune responses and contributions of epithelial cells to immune regulation. Recent evidence suggesting that epithelial cells play an active role in inducing several of the structural changes, collectively referred to airway remodeling, seen in the airways of asthmatic subjects is reviewed. Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function.
AbstractList The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory status, structure, and function in normal and diseased airways. This article reviews our current knowledge regarding the roles of the epithelial cell in airway inflammation and host defense. The interactions of inhaled environmental factors and pathogens with epithelial cells are also discussed, with an emphasis on epithelial innate immune responses and contributions of epithelial cells to immune regulation. Recent evidence suggesting that epithelial cells play an active role in inducing several of the structural changes, collectively referred to airway remodeling, seen in the airways of asthmatic subjects is reviewed. Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function.
The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory status, structure, and function in normal and diseased airways. This article reviews our current knowledge regarding the roles of the epithelial cell in airway inflammation and host defense. The interactions of inhaled environmental factors and pathogens with epithelial cells are also discussed, with an emphasis on epithelial innate immune responses and contributions of epithelial cells to immune regulation. Recent evidence suggesting that epithelial cells play an active role in inducing several of the structural changes, collectively referred to airway remodeling, seen in the airways of asthmatic subjects is reviewed. Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function.The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway diseases. As such, epithelial cells are now recognized to play a central role in the regulation of airway inflammatory status, structure, and function in normal and diseased airways. This article reviews our current knowledge regarding the roles of the epithelial cell in airway inflammation and host defense. The interactions of inhaled environmental factors and pathogens with epithelial cells are also discussed, with an emphasis on epithelial innate immune responses and contributions of epithelial cells to immune regulation. Recent evidence suggesting that epithelial cells play an active role in inducing several of the structural changes, collectively referred to airway remodeling, seen in the airways of asthmatic subjects is reviewed. Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function.
Author Proud, David
Leigh, Richard
Author_xml – sequence: 1
  givenname: David
  surname: Proud
  fullname: Proud, David
  organization: Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
– sequence: 2
  givenname: Richard
  surname: Leigh
  fullname: Leigh, Richard
  organization: Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21682746$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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2011 John Wiley & Sons A/S.
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2009; 89
2004; 287
2010; 10
2005; 171
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2008; 32
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1996; 269
2006; 177
2007; 179
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2007; 293
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1995; 8
2001; 276
2004; 55
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2006; 41
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2006; 43
2000; 105
2004; 59
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1992; 258
2005; 5
2003; 24
1994; 11
2007; 81
2003; 28
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2001; 31
2000; 181
2009; 40
2003; 15
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2001; 107
2008; 73
2003; 112
2006; 414
2003; 111
2007; 36
2005; 23
2007; 37
1993; 6
1994; 343
1991; 143
1992; 90
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2006; 61
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1997; 185
2000; 55
2005; 303
1999; 14
2010; 155
2000; 161
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2000; 162
2010; 391
2008; 64
2006; 368
2006; 129
2008; 153
2005; 33
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1995; 91
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1996; 153
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Snippet The airway epithelial cell is the initial cell type impacted both by inhaled environmental factors, such as pathogens, allergens, and pollutants, and inhaled...
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SubjectTerms airway remodeling
Airway Remodeling - immunology
Allergens
Allergens - immunology
Animals
Asthma
Asthma - drug therapy
Asthma - immunology
Asthma - physiopathology
Bronchodilator Agents - therapeutic use
Cell Adhesion Molecules - immunology
Child
Cytokines - immunology
Drugs
Environmental factors
epithelial cell
Epithelial cells
Epithelial Cells - drug effects
Epithelial Cells - immunology
Epithelial Cells - metabolism
Epithelium
Epithelium - drug effects
Epithelium - immunology
Epithelium - metabolism
host defense
Humans
Hypersensitivity - drug therapy
Hypersensitivity - immunology
Hypersensitivity - physiopathology
Immune response
Immunity, Innate
Immunoregulation
inflammation
Inflammation - immunology
innate immunity
Intercellular Signaling Peptides and Proteins - immunology
Mice
Mice, Knockout
Pathogens
Picornaviridae Infections - immunology
Picornaviridae Infections - virology
Pollutants
Respiratory System - drug effects
Respiratory System - immunology
Respiratory System - physiopathology
Respiratory tract diseases
Respiratory Tract Infections - immunology
Respiratory Tract Infections - virology
Reviews
Rhinovirus - immunology
Rhinovirus - physiology
Signal Transduction - immunology
Structure-function relationships
Title Epithelial cells and airway diseases
URI https://api.istex.fr/ark:/67375/WNG-D9WB7RGM-X/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1600-065X.2011.01033.x
https://www.ncbi.nlm.nih.gov/pubmed/21682746
https://www.proquest.com/docview/873122804
https://www.proquest.com/docview/883042202
Volume 242
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