Copper-Catalyzed Intramolecular Desymmetric Aryl CO Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans

• Published in: Angewandte Chemie International Edition Vol. 54; no. 30; pp. 8805 - 8808
• Main Authors: Yang, Wenqiang, Liu, Yangyuan, Zhang, Shasha, Cai, Qian
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 20.07.2015; WILEY‐VCH Verlag
• Subjects: 2,3‐dihydrobenzofuran; 3-dihydrobenzofuran; Aromatic compounds; asymmetric catalysis; Benzofurans - chemical synthesis; Benzofurans - chemistry; Carbon; Catalysis; Catalysts; Chromans - chemical synthesis; Chromans - chemistry; Compatibility; copper; Copper - chemistry; desymmetrization; Joining; Ligands; O-arylation; Stereoisomerism; Strategy; O-arylation; copper; 2,3-dihydrobenzofuran; desymmetrization; asymmetric catalysis

O‐Heterocyclic structures such as 2,3‐dihydrobenzofurans are key motifs in many natural compounds and pharmaceuticals. Enantioselective formation of chiral dihydrobenzofurans and analogues was achieved through a copper‐catalyzed desymmetrization strategy with a chiral cyclic 1,2‐diamine. A broad ran...