Experimental evaluation of single‐domain antibodies predicted by molecular dynamics simulations to have elevated thermal stability - Zabetakis, Dan; Shriver‐Lake, Lisa C.; Olson, Mark A.; Goldman, Ellen R.; Anderson, George P. (Protein science, 2019)
Keywords: Affinity; Amino acids; Antibodies; Asparagine; Aspartic acid; Cholera; Cholera toxin; Complementarity-determining region 1; Computer applications; Computer simulation; Crystal structure; Dynamic stability; For the Record; High temperature; Immunoglobulins; Melting point; Melting points; Models, Molecular; Molecular dynamics; Molecular Dynamics Simulation; molecular dynamics simulations; Mutation; Nanobodies; Predictions; Protein Aggregates; Protein Stability; protein stabilization; Proteins; Simulation; Single-Domain Antibodies - chemistry; Single-Domain Antibodies - genetics; single‐domain antibody; Temperature; Thermal stability; Toxins; Waterborne diseases; molecular dynamics simulations; thermal stability; protein stabilization; single-domain antibody