Assessment of Genetic Ancestry and Population Substructure in Costa Rica by Analysis of Individuals with a Familial History of Mental Disorder

• Published in: Annals of human genetics Vol. 74; no. 6; pp. 516 - 524
• Main Authors: Segura‐Wang, Maia, Raventós, Henriette, Escamilla, Michael, Barrantes, Ramiro
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.11.2010
• Subjects: admixture; Africa; African Continental Ancestry Group - genetics; American Native Continental Ancestry Group - genetics; ancestry; Costa Rica; Ethnic Groups - genetics; European Continental Ancestry Group - genetics; Female; Gene Flow; Gene Frequency; Genetic diversity; Genetic drift; Genetic structure; Genetic Variation; Genetics, Population; Genotype; Humans; Male; Mental disorders; Mental Disorders - genetics; Microsatellite Repeats; Microsatellites; Population genetics; Population levels; Principal Component Analysis; Reproduction; STRs; Africa; Costa Rica

Summary The population of Costa Rica has been considered valuable for locating susceptibility genes of complex disorders because of historical events and a gradual admixture process. We present an assessment of 426 unrelated individuals with a familial history of mental disorder and with ancestors b...