Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects - Graham, Richard A.; Hop, Cornelis E. C. A.; Borin, Marie T.; Lum, Bert L.; Colburn, Dawn; Chang, Ilsung; Shin, Young G.; Malhi, Vikram; Low, Jennifer A.; Dresser, Mark J. (British journal of clinical pharmacology, 2012)
Keywords: absolute bioavailability; Anilides - administration & dosage; Anilides - pharmacokinetics; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacokinetics; Biological and medical sciences; Biological Availability; Blood Proteins - metabolism; Chromatography, Liquid; clearance; Drug Administration Schedule; Female; GDC‐0449; Half-Life; Humans; Injections, Intravenous; Mass Spectrometry - methods; Medical sciences; Middle Aged; Nonlinear Dynamics; of distribution; Pharmacokinetics; Pharmacology. Drug treatments; Protein Binding; Pyridines - administration & dosage; Pyridines - pharmacokinetics; Solubility; Tandem Mass Spectrometry; Tissue Distribution; vismodegib; volume; Human; Intravenous administration; Healthy subject; Single dose; Oral administration; of distribution; vismodegib; Bioavailability; Clearance; Multiple dose; GDC-0449; volume; Hedgehog protein; absolute bioavailability; Distribution; Inhibitor; Pharmacokinetics