Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes - Tanaka, Atsushi; Yuasa, Shinsuke; Mearini, Giulia; Egashira, Toru; Seki, Tomohisa; Kodaira, Masaki; Kusumoto, Dai; Kuroda, Yusuke; Okata, Shinichiro; Suzuki, Tomoyuki; Inohara, Taku; Arimura, Takuro; et al. (Journal of the American Heart Association, 2014)
Keywords: Animals; Biomechanical Phenomena; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - pathology; Cardiomegaly - physiopathology; Cardiomyopathy, Hypertrophic - metabolism; Cardiomyopathy, Hypertrophic - pathology; Cardiomyopathy, Hypertrophic - physiopathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Case-Control Studies; Cell Differentiation; Cells, Cultured; disease modeling; Dose-Response Relationship, Drug; Endothelin-1 - pharmacology; ET‐1; Gene-Environment Interaction; Genotype; HCM; Humans; Induced Pluripotent Stem Cells - drug effects; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - pathology; iPS cells; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; MYBPC3; Myocardial Contraction - drug effects; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Myofibrils - drug effects; Myofibrils - metabolism; Myofibrils - pathology; Original Research; Phenotype; Risk Factors; Signal Transduction - drug effects; Time Factors; Transfection; Ventricular Dysfunction - genetics; Ventricular Dysfunction - metabolism; Ventricular Dysfunction - pathology; Ventricular Dysfunction - physiopathology; MYBPC3; HCM; ET‐1; disease modeling; iPS cells