Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects

• Published in: Clinical pharmacology in drug development Vol. 6; no. 1; pp. 66 - 75
• Main Authors: Yamazaki, Takao, Desai, Amit, Goldwater, Ronald, Han, David, Lasseter, Kenneth C., Howieson, Corrie, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Rammelsberg, Diane, Townsend, Robert
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017; John Wiley and Sons Inc
• Subjects: Adult; Area Under Curve; atorvastatin; Atorvastatin Calcium - administration & dosage; digoxin; Digoxin - administration & dosage; Drug dosages; Female; Healthy Volunteers; Humans; isavuconazole; Male; Membrane Transport Proteins - metabolism; metformin; Metformin - administration & dosage; methotrexate; Methotrexate - administration & dosage; Middle Aged; Nitriles - administration & dosage; Nitriles - pharmacokinetics; Original Manuscript; Pyridines - administration & dosage; Pyridines - pharmacokinetics; Triazoles - administration & dosage; Triazoles - pharmacokinetics; Young Adult; metformin; methotrexate; isavuconazole; digoxin; atorvastatin

This article summarizes 4 phase 1 trials that explored interactions between the novel, triazole antifungal isavuconazole and substrates of the drug transporters breast cancer resistance protein (BCRP), multidrug and toxin extrusion protein‐1 (MATE1), organic anion transporters 1/3 (OAT1/OAT3), organ...