Dissecting the human immunologic memory for pathogens

Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental...

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Published inImmunological reviews Vol. 240; no. 1; pp. 40 - 51
Main Authors Zielinski, Christina E., Corti, Davide, Mele, Federico, Pinto, Dora, Lanzavecchia, Antonio, Sallusto, Federica
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.2011
Subjects
analytic vaccinology
Animal models
B cells
B-Lymphocytes - immunology
Cell culture
Drug Design
Host-Pathogen Interactions
Humans
Immunologic Memory
Immunological memory
Lymphocytes B
Lymphocytes T
Memory cells
Pathogens
Plasma cells
Reviews
T cells
T-Lymphocytes - immunology
Vaccines
Vaccines - immunology
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Abstract Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as ‘analytic vaccinology’.
AbstractList Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as 'analytic vaccinology'.
Author Lanzavecchia, Antonio
Zielinski, Christina E.
Mele, Federico
Sallusto, Federica
Corti, Davide
Pinto, Dora
Author_xml – sequence: 1
  givenname: Christina E.
  surname: Zielinski
  fullname: Zielinski, Christina E.
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
– sequence: 2
  givenname: Davide
  surname: Corti
  fullname: Corti, Davide
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
– sequence: 3
  givenname: Federico
  surname: Mele
  fullname: Mele, Federico
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
– sequence: 4
  givenname: Dora
  surname: Pinto
  fullname: Pinto, Dora
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
– sequence: 5
  givenname: Antonio
  surname: Lanzavecchia
  fullname: Lanzavecchia, Antonio
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
– sequence: 6
  givenname: Federica
  surname: Sallusto
  fullname: Sallusto, Federica
  organization: Institute for Research in Biomedicine, Bellinzona, Switzerland
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21349085$$D View this record in MEDLINE/PubMed
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1997; 86
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2002; 111
2006; 36
2010; 143
2008; 9
2004; 5
2008; 8
2009; 119
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2006; 211
2003; 198
2000; 290
2007; 28
2007; 178
2001; 410
2000; 18
2009; 10
2010; 1
2001; 291
1994; 180
2010; 28
1991; 88
2008; 29
2005; 105
1993; 75
2007; 8
2003; 4
2007; 4
2007; 63
2009; 206
2010; 3
2009; 15
1998; 11
2005; 79
2007; 27
2001; 98
2006; 443
2010; 8
2007; 445
2007; 19
2010; 32
2006; 439
1990; 249
2004; 103
2007; 204
2009; 21
2010; 207
2005; 115
2002; 298
2005; 41
2002; 2
2008; 205
2006; 6
2010; 120
2006; 358
2009; 27
2010; 84
2009; 458
2004; 10
2007; 357
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Snippet Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection...
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SubjectTerms analytic vaccinology
Animal models
B cells
B-Lymphocytes - immunology
Cell culture
Drug Design
Host-Pathogen Interactions
Humans
Immunologic Memory
Immunological memory
Lymphocytes B
Lymphocytes T
Memory cells
Pathogens
Plasma cells
Reviews
T cells
T-Lymphocytes - immunology
Vaccines
Vaccines - immunology
Title Dissecting the human immunologic memory for pathogens
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https://www.ncbi.nlm.nih.gov/pubmed/21349085
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https://search.proquest.com/docview/879473102
Volume 240
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